ArticleThe Egyptian journal of neurology, psychiatry and neurosurgery2021
Unexplained worsening of parkinsonian symptoms in a patient with advanced Parkinson's disease as the sole initial presentation of COVID-19 infection: a case report.
Article in The Egyptian journal of neurology, psychiatry and neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 6 citations in OpenAlex.
- Does COVID-19 Trigger the Risk for the Development of Parkinson's Disease? Therapeutic Potential of Vitamin C.Molecular neurobiology · 2024Review
- Viral Parkinsonism: An underdiagnosed neurological complication of Dengue virus infection.PLoS neglected tropical diseases · 2022Article
- Is SARS-CoV-2 responsible for relapses of Parkinson's disease?The Egyptian journal of neurology, psychiatry and neurosurgery · 2021Article
- Reply to Letter to Editor: Is SARS-CoV-2 responsible for relapses of Parkinson's disease?The Egyptian journal of neurology, psychiatry and neurosurgery · 2021Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
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Abstract
backgroundParkinson's disease (PD) is a neurodegenerative condition that has been reported following viral infections in rare occasions. Several neurological complications have emerged in association with coronavirus disease 2019 (COVID-19), since its declaration as a pandemic. Herein, we present a novel case of unexplained worsening of PD as the sole initial presentation of COVID-19, in the absence of fever or respiratory symptoms. CASE PRESENTATION: A 56-year-old male with advanced PD presented with severe rigidity, dystonic posturing of both feet, and confusion of 4 days duration. His condition progressed to an akinetic-rigid state and confusion during the following week, and a routine nasopharyngeal swab tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the 9th day of onset. He developed fever and dyspnea later and was intubated on the 10th day.
conclusionTo our knowledge, worsening of PD symptoms as the sole initial manifestation of SARS-CoV-2 infection, in the absence of other cardinal features of COVID-19, has not been reported in the literature. We suggest testing for COVID-19 infection in patients with PD, especially advanced cases, who present with unexplained worsening of symptoms, even in the absence of COVID-19 cardinal features.
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