ArticleJournal of clinical biochemistry and nutrition2021
Serum uric acid and risk of stroke: a dose-response meta-analysis.
Article in Journal of clinical biochemistry and nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evidence for a dose-response association of hyperuricemia with stroke incidence: a meta-analysis of cohort studies.Frontiers in neurology · 2026Pooled it
- The Nonlinear Relationship Between Serum Uric Acid and Cardiovascular Disease Risk: Mechanistic Insights and Clinical Implications.Cardiovascular drugs and therapy · 2026Review
- Uric acid-to-HDL cholesterol ratio and incident stroke: Competing-risk models in the China Health and Retirement Longitudinal Study.Medicine · 2026Article
- Machine learning increases the prediction of stroke for Chinese hypertensive patients.Frontiers in microbiology · 2026Article
- Serum Uric Acid Levels Associated with Outcomes of Neurodegenerative Disorders and Brain Health: Findings from the UK Biobank.The journal of nutrition, health & aging · 2024Article
- Exploring the Multifaceted Nexus of Uric Acid and Health: A Review of Recent Studies on Diverse Diseases.Biomolecules · 2023Review
- A cross-sectional analysis of the relationship between ischemic stroke and uric acid in young people in highland areas.Frontiers in endocrinology · 2023Article
- Non-linear dose-response relationship between body mass index and stroke risk in middle-aged and elderly Chinese men: a nationwide Longitudinal Cohort Study from CHARLS.Frontiers in endocrinology · 2023Article
- The Impact of an Elevated Uric Acid Level on the Prevalence of Coronary Artery Disease in Pancreas Transplant Candidates with Type 1 Diabetes: A Cross Sectional Study.Journal of clinical medicine · 2022Article
- Association of Uric Acid With Blood Pressure in Hypertension Between Treatment Group and Non-treatment Group.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between serum uric acid and risk of stroke is still controversial. Therefore, we conducted a meta-analysis based on the cohort study to explore the relationship between serum uric acid and risk of stroke, and further illuminate whether there is a linear or non-linear relationship between them. We manually searched the database including Cochrane, PubMed, Embase, Web of Science, and selected cohort studies focusing on the relationship between serum uric acid and stroke risk. Random effect model was used for statistical analysis. Twenty-one cohort studies involving 818,098 participants were included. The pooled relative risk for the high-vs-low categories was 1.22 (95% CI: 1.15-1.30). In addition, there was a non-linear dose-response relationship between uric acid and stroke risk. Serum uric acid was in the range of 3-5 mg/dl, with the lowest risk of stroke. In conclusion, high serum uric acid level increases the risk of stroke, with a non-linear dose-response relationship.
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