ArticleJournal of aerosol science2021
Efficient bi-directional coupling of 3D Computational Fluid-Particle Dynamics and 1D Multiple Path Particle Dosimetry lung models for multiscale modeling of aerosol dosimetry.
Article in Journal of aerosol science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum.American journal of physiology. Heart and circulatory physiology · 2024Guideline
- Aerodynamic barriers to inhaled furosemide delivery during dyspnoea revealed by experimental and computational modelling.Scientific reports · 2026Article
- In silico high-resolution whole lung model to predict the locally delivered dose of inhaled drugs.Communications medicine · 2026Article
- Modeling aerosol bolus inhalations in the human lung with the Multiple Path Particle Deposition model: Comparison with experimental data.Journal of aerosol science · 2025Article
- Perspectives on physics-based one-dimensional modeling of lung physiology.Frontiers in physiology · 2025Article
- Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety.Frontiers in toxicology · 2025Article
- Subject-Specific Multi-Scale Modeling of the Fate of Inhaled Aerosols.Journal of aerosol science · 2025Article
- Experimental Full-volume Airway Approximation for Assessing Breath-dependent Regional Aerosol Deposition.Device · 2024Article
- Non-local impact of distal airway constrictions on patterns of inhaled particle deposition.Royal Society open science · 2024Article
- The effects of airway disease on the deposition of inhaled drugs.Expert opinion on drug delivery · 2024Review
- Article
- Automated bidirectional coupling of multiscale models of aerosol dosimetry: validation with subject-specific deposition data.Journal of aerosol science · 2023Article
- A Pediatric Upper Airway Library to Evaluate Interpatient Variability of In Silico Aerosol Deposition.AAPS PharmSciTech · 2023Article
- Article
- Spatial aerosol deposition correlated to anatomic feature development in 6-year-old upper airway computational models.Computers in biology and medicine · 2022Article
- Human exposure to metals in consumer-focused fused filament fabrication (FFF)/ 3D printing processes.The Science of the total environment · 2022Review
- Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations.Frontiers in physiology · 2022Review
- Advancing therapies for viral infections using mechanistic computational models of the dynamic interplay between the virus and host immune response.Current opinion in virology · 2021Review
- New Approach Methodology for Assessing Inhalation Risks of a Contact Respiratory Cytotoxicant: Computational Fluid Dynamics-Based Aerosol Dosimetry Modeling for Cross-Species and In Vitro Comparisons.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- How severe acute respiratory syndrome coronavirus-2 aerosol propagates through the age-specific upper airways.Physics of fluids (Woodbury, N.Y. : 1994) · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
The development of predictive aerosol dosimetry models has been a major focus of environmental toxicology and pharmaceutical health research for decades. One-dimensional (1D) models successfully predict overall deposition averages but fail to accurately predict local deposition. Computational fluid-particle dynamics (CFPD) models provide site-specific predictions but at a computational cost that prohibits whole lung predictions. Thus, there is a need for developing multiscale strategies to provide a realistic subject-specific picture of the fate of inhaled aerosol in the lungs. CT-based 3D/CFPD models of the large airways were bidirectionally coupled with individualized 1D Navier-Stokes airflow and particle transport based upon the widely used Multiple Path Particle Dosimetry Model (MPPD). Distribution of airflows among lobes was adjusted by measured lobar volume changes observed in CT images between FRC and FRC + 1.5 L. As a test of the effectiveness of the coupling procedures, deposition modeling of previous 1 μm aerosol exposure studies was performed. The complete coupled model was run for 3 breaths, with the computation-intense portion being the 3D CFPD Lagrangian particle tracking calculation. The average deposition per breath was 11% in the combined multiscale model with site-specific doses available in the CFPD portion of the model and airway- or region-specific deposition available for the MPPD portion. In conclusion, the key methods developed in this study enable predictions of ventilation heterogeneities and aerosol deposition across the lungs that are not captured by 3D or 1D models alone. These methods can be used as the foundation for multi-scale modeling of the full respiratory system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.