SynthesisInternational journal of obesity (2005)2021
Evidence for a causal association between milk intake and cardiometabolic disease outcomes using a two-sample Mendelian Randomization analysis in up to 1,904,220 individuals.
Synthesis in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Research Progress in Multi-Omics Analysis of Dairy Products: Nutritional Quality, Safety Evaluation, and Health Functions.Foods (Basel, Switzerland) · 2026Review
- Article
- Dairy Consumption and Risk of Cardiometabolic Diseases: A Prospective Cohort Study of the China Kadoorie Biobank.The Journal of nutrition · 2026Article
- Impact of Milk Consumption and Dietary Patterns on Pelvic Organ Prolapse: A Mendelian Randomization Study.International journal of women's health · 2025Article
- Exploring the Interplay of Genetics and Nutrition in the Rising Epidemic of Obesity and Metabolic Diseases.Nutrients · 2024Review
- Article
- Development and Validation of the Meiji Nutritional Profiling System per Serving Size.Nutrients · 2024Article
- Development and Validation of the Meiji Nutritional Profiling System (Meiji NPS) to Address Dietary Needs of Adults and Older Adults in Japan.Nutrients · 2024Article
- Association of different milk fat content with coronary artery disease and myocardial infarction risk: A Mendelian randomization study.PloS one · 2024Article
- Milk and dairy products - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2024Article
- Milk protects against sarcopenic obesity due to increase in the genus Akkermansia in faeces of db/db mice.Journal of cachexia, sarcopenia and muscle · 2023Article
- Expression profiles of east-west highly differentiated genes in Uyghur genomes.National science review · 2023Article
- Implementation of Nutrigenetics and Nutrigenomics Research and Training Activities for Developing Precision Nutrition Strategies in Malaysia.Nutrients · 2022Review
- Higher Intake of Dairy Is Associated with Lower Cardiometabolic Risks and Metabolic Syndrome in Asian Indians.Nutrients · 2022Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundHigh milk intake has been associated with cardio-metabolic risk. We conducted a Mendelian Randomization (MR) study to obtain evidence for the causal relationship between milk consumption and cardio-metabolic traits using the lactase persistence (LCT-13910 C > T, rs4988235) variant as an instrumental variable.
methodsWe tested the association of LCT genotype with milk consumption (for validation) and with cardio-metabolic traits (for a possible causal association) in a meta-analysis of the data from three large-scale population-based studies (1958 British Birth Cohort, Health and Retirement study, and UK Biobank) with up to 417,236 participants and using summary statistics from consortia meta-analyses on intermediate traits (N = 123,665-697,307) and extended to cover disease endpoints (N = 86,995-149,821).
resultsIn the UK Biobank, carriers of 'T' allele of LCT variant were more likely to consume milk (P = 7.02 × 10
conclusionsOur large-scale MR study provides genetic evidence for the association of milk consumption with higher BMI but lower serum cholesterol levels. These data suggest no need to limit milk intakes with respect to cardiovascular disease risk, with the suggested benefits requiring confirmation in further studies.
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