ArticleMolecular psychiatry2021
White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis.
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Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Baseline symptom-related white matter tracts predict individualized treatment response to 12-week antipsychotic monotherapies in first-episode schizophrenia.Translational psychiatry · 2024Trial
- Schizophrenia: Converging Neurobiological Mechanisms and Emerging Therapeutic Strategies.Biomolecules · 2026Review
- Disentangling white matter correlates of symptom severity and general impairment in early psychosis.Molecular psychiatry · 2026Article
- Decoding Psychosis Risk: Neuroanatomical Correlates of the NAPLS-2 Calculator in the PRONIA Cohort.Schizophrenia bulletin · 2026Article
- Deep learning-based Desikan-Killiany parcellation of the brain using diffusion MRI.Scientific reports · 2026Article
- Myo-inositol concentration in the medial prefrontal cortex is associated with changes in brain white matter microstructure in early psychosis.Translational psychiatry · 2026Article
- Altered white matter integrity in pediatric bipolar disorder and the potential role of psychotic symptoms revealed by free water elimination corrected and superficial white matter DTI analyses.European child & adolescent psychiatry · 2026Article
- Saturated Fatty Acids and White Matter Microstructure in Individuals With At-risk Mental State.Schizophrenia bulletin · 2026Article
- Repurposing medications to prevent psychosis.Npj mental health research · 2025Review
- Differential trajectories of corticostriatal structural connectivity in individuals at clinical high risk for psychosis according to functional outcome.Translational psychiatry · 2025Article
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- White matter microstructure alterations in early psychosis and schizophrenia.Translational psychiatry · 2025Article
- Stable White Matter Structure in the First Three Years After Psychosis Onset.Biological psychiatry global open science · 2025Article
- Data analysis strategies for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- The MR neuroimaging protocol for the Accelerating Medicines Partnership® Schizophrenia Program.Schizophrenia (Heidelberg, Germany) · 2025Article
- Modulation and distribution of extracellular free water and tract deficits in rhesus macaques before and after the initiation of emtricitabine + tenofovir disoproxil fumarate + dotutegravir treatment.Frontiers in immunology · 2025Article
- A narrative literature review of white matter microstructure in individuals at clinical high risk for psychosis.Psychoradiology · 2025Review
- Parsing heterogeneity in global and local white matter integrity at different stages across the psychosis continuum.Schizophrenia (Heidelberg, Germany) · 2024Article
- Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- DDParcel: Deep Learning Anatomical Brain Parcellation From Diffusion MRI.IEEE transactions on medical imaging · 2024Article
Corrections and comments
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Authors and funding
30 authors at 10 institutions in 3 countries.
Maria A Di BiaseDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. dibiasem@unimelb.edu.au.ORCID http://orcid.org/0000-0002-7100-651X
Suheyla Cetin-KarayumakDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3315-5821
Amanda E LyallDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-8049-516X
Andrew ZaleskyMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia.
Kang Ik Kevin ChoDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Fan ZhangDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5032-6039
Marek KubickiDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3989-8212
Yogesh RathiDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Monica G LyonsDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sylvain BouixDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1326-6054
Tashrif BillahDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alan AnticevicDepartment of Psychiatry and Psychology, Yale University, New Haven, CT, USA.
Charlie SchleiferUCLA School of Medicine, Los Angeles, CA, USA.
Brendan D AdkinsonYale Interdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
Jie Lisa JiDepartment of Psychiatry and Psychology, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-6280-9070
Zailyn TamayoDepartment of Psychiatry and Psychology, Yale University, New Haven, CT, USA.
Jean AddingtonHotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-8298-0756
Carrie E BeardenDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior and Department of Psychology, University of California-Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8516-923X
Barbara A CornblattDepartment of Psychiatry and Psychology, The Feinstein Institute for Medical Research, Manhasset, NY, USA.
Matcheri S KeshavanHarvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
Daniel H MathalonUniversity of California, San Francisco, San Francisco, CA, USA.
Thomas H McGlashanDepartment of Psychiatry and Psychology, Yale University, New Haven, CT, USA.
Diana O PerkinsDepartment of Psychology, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA.
Kristen S CadenheadDepartment of Psychiatry, University of California San Diego (UCSD), La Jolla, CA, USA.
Ming T TsuangDepartment of Psychiatry, University of California San Diego (UCSD), La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-0076-5340
Scott W WoodsDepartment of Psychiatry and Psychology, Yale University, New Haven, CT, USA.
William S StoneHarvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
Martha E ShentonDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Tyrone D CannonDepartment of Psychiatry and Psychology, Yale University, New Haven, CT, USA.
Ofer PasternakDepartment of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-7078-6446
Brigham and Women's Hospital · USYale University · USBeth Israel Deaconess Medical Center · USUniversity of California, Los Angeles · USUniversity of California San Diego · USFeinstein Institute for Medical Research · USSan Francisco VA Medical Center · USThe University of Melbourne · AUUniversity of Calgary · CAUniversity of North Carolina at Chapel Hill · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MTraining and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9MMedical Scientist Training ProgramT32GM136651 · NIGMS · YALE UNIVERSITY · PI BARBARA I KAZMIERCZAK · 2020 to 2026
$16.5M1/9 Predictors and Mechanisms of Conversion to PsychosisU01MH081902 · NIMH · YALE UNIVERSITY · PI CANNON, TYRONE D · 2008 to 2018
$12.4MNovel DT-MRI Analyses of White Matter in SchizophreniaR01MH074794 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI WESTIN, CARL-FREDRIK · 2007 to 2021
$9.6M5/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082004 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PERKINS, DIANA O. · 2008 to 2018
$7.5MAdministrative Supplement Harmonization of At Risk Multisite Observational Networks for Youth(HARMONY)U01MH081928 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI STONE, WILLIAM SETH · 2008 to 2018
$7.1M4/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081857 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORNBLATT, BARBARA A. · 2008 to 2018
$6.2M8/9 Predictors and Mechanisms of Conversion to PsychosisU01MH082022 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 2008 to 2018
$6.0MHuman Connectome Project for Early PsychosisU01MH109977 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI BREIER, ALAN, SHENTON, MARTHA E. · 2016 to 2020
$5.5M6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M"7/9" Predictors and Mechanisms of Conversion to PsychosisU01MH081984 · NIMH · UNIVERSITY OF CALGARY · PI ADDINGTON, JEAN M · 2008 to 2018
$4.2MNCATS NIH HHS UL1 TR001863NIBIB NIH HHS P41 EB015902NIGMS NIH HHS T32 GM136651NIMH NIH HHS K01 MH115247NIMH NIH HHS R01 MH074794NIMH NIH HHS R01 MH102377NIMH NIH HHS R01 MH108574NIMH NIH HHS U01 MH076989NIMH NIH HHS U01 MH081857NIMH NIH HHS U01 MH081902NIMH NIH HHS U01 MH081928NIMH NIH HHS U01 MH081944NIMH NIH HHS U01 MH081984NIMH NIH HHS U01 MH082004NIMH NIH HHS U01 MH082022NIMH NIH HHS U01 MH109977
Abstract
Subtle alterations in white matter microstructure are observed in youth at clinical high risk (CHR) for psychosis. However, the timing of these changes and their relationships to the emergence of psychosis remain unclear. Here, we track the evolution of white matter abnormalities in a large, longitudinal cohort of CHR individuals comprising the North American Prodrome Longitudinal Study (NAPLS-3). Multi-shell diffusion magnetic resonance imaging data were collected across multiple timepoints (1-5 over 1 year) in 286 subjects (aged 12-32 years): 25 CHR individuals who transitioned to psychosis (CHR-P; 61 scans), 205 CHR subjects with unknown transition outcome after the 1-year follow-up period (CHR-U; 596 scans), and 56 healthy controls (195 scans). Linear mixed effects models were fitted to infer the impact of age and illness-onset on variation in the fractional anisotropy of cellular tissue (FA
Indexed as
Psychotic DisordersWhite MatterAdolescentAdultChildChild, PreschoolCorpus CallosumHumansLongitudinal StudiesProdromal SymptomsYoung Adult
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