Observational studyJournal of Parkinson's disease2021
The Parkinson's Real-World Impact Assessment (PRISM) Study: A European Survey of the Burden of Parkinson's Disease in Patients and their Carers.
Observational study in Journal of Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Advanced Parkinson's disease treatment patterns in Italy: results from a multicenter observational study.Annals of medicine · 2026Observational
- Range of Motion and Intensity Achieved During a Single Session of Targeted Robot-Assisted Exercise in Individuals with Parkinson's Disease: A Pilot Study.Sensors (Basel, Switzerland) · 2026Article
- Evaluation and management of male sexual dysfunction in Parkinson's disease: A clinical road map.Journal of Parkinson's disease · 2026Review
- Non-motor symptoms as critical predictors of quality of life in Parkinson's disease: a machine learning approach.Health and quality of life outcomes · 2025Observational
- Factors Influencing Pain Management Practices in People With Parkinson's Disease: A Qualitative Descriptive Study.Parkinson's disease · 2025Article
- Predicting Quality of Life in Parkinson's Disease: A Machine Learning Approach Employing Common Clinical Variables.Journal of clinical medicine · 2024Article
- Enhancing recruitment of individuals living with frailty, multimorbidity and cognitive impairment to Parkinson's research: experiences from the PRIME-UK cross-sectional study.Age and ageing · 2024Article
- Dopaminergic treatment strategies for people with Parkinson's disease in Europe: a retrospective analysis of PRISM trial data.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Contributory Factors to Caregiver Burden in Parkinson's Disease.Movement disorders clinical practice · 2023Article
- Effectiveness and safety of safinamide in routine clinical practice in a Belgian Parkinson's disease population: an open-label, levodopa add-on study.Acta neurologica Belgica · 2023Article
- Impact of advanced Parkinson's disease on caregivers: an international real-world study.Journal of neurology · 2023Article
- Impact of Parkinson's Disease on Caregiver Quality of Life in Japan.Movement disorders clinical practice · 2023Article
- Sexual Dysfunctions in Parkinson's Disease and Their Influence on Partnership-Data of the PRISM Study.Brain sciences · 2022Article
- Patient-Related Factors Influencing Caregiver Burden in Parkinson's Disease Patients: Comparison of Effects Before and After Deep Brain Stimulation.Journal of Parkinson's disease · 2022Article
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA greater understanding of the everyday experiences of people with Parkinson's disease (PD) and their carers may help improve clinical practice.
objectiveThe Parkinson's Real-world Impact assesSMent (PRISM) study evaluated medication use, health-related quality of life (HRQoL) and the use of healthcare resources by people with PD and their carers.
methodsPRISM is an observational cross-sectional study, in which people with PD and their carers completed an online survey using structured questionnaires, including the Parkinson's Disease Quality of Life Questionnaire (PDQ-39), Non-Motor Symptoms Questionnaire (NMSQuest) and Zarit Burden Interview (ZBI).
resultsData were collected from 861 people with PD (mean age, 65.0 years; mean disease duration, 7.7 years) and 256 carers from six European countries. People with PD reported a large number of different co-morbidities, non-motor symptoms (mean NMSQuest score, 12.8), and impaired HRQoL (median PDQ-39 summary score, 29.1). Forty-five percent of people with PD reported at least one impulse control behaviour. Treatment patterns varied considerably between different European countries. Levodopa was taken in the last 12 months by 85.9% of participants, and as monotherapy by 21.8%. Carers, who were mostly female (64.8%) and the partner/spouse of the person with PD (82.1%), reported mild to moderate burden (mean ZBI total score, 26.6).
conclusionsThe PRISM study sheds light on the lives of people with PD and those who care for them, re-emphasising the many challenges they face in everyday life. The study also provides insights into the current treatment of PD in Europe.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.