Evidence map›Paper›PMID 34024757›Full record

ArticleJournal of cardiovascular computed tomography

Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease - Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study.

Marc Dewey, Carlos E Rochitte, Mohammad R Ostovaneh, Marcus Y Chen, Richard T George, Hiroyuki Niinuma, Kakuya Kitagawa, Roger Laham, Klaus Kofoed, Cesar Nomura and 22 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular computed tomography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00934037 (Multi Center Combined Non-invasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Computed Tomography), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00934037 phase3completednot on this map

Multi Center Combined Non-invasive Coronary Angiography and Myocardial Perfusion Imaging Using 320-Detector Computed Tomography

TypeinterventionalSponsorJohns Hopkins UniversityRan2009 to 2017Enrolled444ConditionsArterial Occlusive Diseases, Coronary Disease, Heart Diseases, Myocardial IschemiaArms320 Volume Detector Computed Tomography, Other: Multidetector Computed Tomography - 320 detectors
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Computed tomographic angiography in coronary artery disease.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023
    Article
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 16 institutions in 8 countries.

Marc DeweyDepartment of Radiology, Charité Medical School-Humboldt, Berlin, Germany.
Carlos E RochitteInCor Heart Institute, University of São Paulo Medical School, Brazil, São Paulo, Brazil.
Mohammad R OstovanehJohns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD, 21287, USA.
Marcus Y ChenCardiology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Richard T GeorgeJohns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD, 21287, USA.
Hiroyuki NiinumaMemorial Heart Center, Iwate Medical University, Morioka, Japan; Department of Radiology, St. Luke's International Hospital, Tokyo, Japan.
Kakuya KitagawaDepartment of Radiology, Mie University Hospital, Tsu, Japan.
Roger LahamBeth Israel Deaconess Medical Center, Harvard University, Boston, Mass, USA.
Klaus KofoedDepartment of Cardiology, Rigs Hospitalet, University of Copenhagen, Denmark.
Cesar NomuraRadiology Sector, Hospital Israelita Albert Einstein, São Paulo, Brazil.
Hajime SakumaDepartment of Radiology, Mie University Hospital, Tsu, Japan.
Kunihiro YoshiokaMemorial Heart Center, Iwate Medical University, Morioka, Japan.
Vishal C MehraJohns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD, 21287, USA.
Masahiro JinzakiKeio University School of Medicine, Tokyo, Japan.
Sachio KuribayashiKeio University School of Medicine, Tokyo, Japan.
Michael LauleDepartment of Medicine/Cardiology, Charité Medical School-Humboldt, Berlin, Germany.
Narinder PaulDepartment of Medical Imaging, Toronto General Hospital, Toronto, Ontario, Canada.
Arthur J ScholteDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Rodrigo CerciJohns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD, 21287, USA.
John HoeMedi-Rad Associates, CT Centre, Mount Elizabeth Hospital, Singapore.
Swee Yaw TanDepartment of Cardiology, National Heart Centre, Singapore.
Frank J RybickiDepartment of Radiology, University of Cincinnati, Cincinnati, OH, USA.
Matthew B MathesonDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Andrea L VavereJohns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD, 21287, USA.
Andrew E AraiCardiology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Julie M MillerJohns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD, 21287, USA.
Christopher CoxDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Jeffrey BrinkerJohns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD, 21287, USA.
Melvin E ClouseBeth Israel Deaconess Medical Center, Harvard University, Boston, Mass, USA.
Marcelo Di CarliDepartment of Nuclear Medicine and Cardiovascular Imaging, Brigham and Women's Hospital, Boston, MA, USA.
João A C LimaJohns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD, 21287, USA.
Armin Arbab-ZadehJohns Hopkins Hospital and School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD, 21287, USA. Electronic address: azadeh1@jhmi.edu.
Johns Hopkins University · USBeth Israel Deaconess Medical Center · USHumboldt-Universität zu Berlin · DEIwate Medical University · JPKeio University · JPMie University Hospital · JPNational Institutes of Health · USBrigham and Women's Hospital · USHospital Israelita Albert Einstein · BRLeiden University Medical Center · NLMount Elizabeth Hospital · SGNational Heart Centre Singapore · SGToronto General Hospital · CAUniversidade de São Paulo · BRUniversity of Cincinnati · USUniversity of Copenhagen · DK

Funding

Cardiovascular CT Clinical ResearchZIAHL006220 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CHEN, MARCUS · 2017 to 2025
$22.5M
Cardiovascular CT ResearchZIAHL006138 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ARAI, ANDREW · 2011 to 2016
$7.3M
Intramural NIH HHS ZIA HL006138Intramural NIH HHS ZIA HL006220
6 · The paper itself

Abstract

backgroundFew data exist on long-term outcome in patients undergoing combined coronary CT angiography (CTA) and myocardial CT perfusion imaging (CTP) as well as invasive coronary angiography (ICA) and single photon emission tomography (SPECT).

methodsAt 16 centers, 381 patients were followed for major adverse cardiac events (MACE) for the CORE320 study. All patients underwent coronary CTA, CTP, and SPECT before ICA within 60 days. Prognostic performance according binary results (normal/abnormal) was assessed by 5-year major cardiovascular events (MACE) free survival and area under the receiver-operating-characteristic curve (AUC).

resultsFollow up beyond 2-years was available in 323 patients. MACE-free survival rate was greater among patients with normal combined CTA-CTP findings compared to ICA-SPECT: 85 vs. 80% (95% confidence interval [CI] for difference 0.1, 11.3) though event-free survival time was similar (4.54 vs. 4.37 years, 95% CI for difference: -0.03, 0.36). Abnormal results by combined CTA-CTP was associated with 3.83 years event-free survival vs. 3.66 years after abnormal combined ICA-SPECT (95% CI for difference: -0.05, 0.39). Predicting MACE by AUC also was similar: 65 vs. 65 (difference 0.1; 95% CI -4.6, 4.9). When MACE was restricted to cardiovascular death, myocardial infarction, or stroke, AUC for CTA-CTP was 71 vs. 60 by ICA-SPECT (difference 11.2; 95% CI -1.0, 19.7).

conclusionsCombined CTA-CTP evaluation yields at least equal 5-year prognostic information as combined ICA-SPECT assessment in patients presenting with suspected coronary artery disease. Noninvasive cardiac CT assessment may eliminate the need for diagnostic cardiac catheterization in many patients. CLINICAL

trial registrationNCT00934037.

Indexed as

Coronary Artery DiseaseMyocardial Perfusion ImagingComputed Tomography AngiographyCoronary AngiographyFollow-Up StudiesHumansPredictive Value of TestsPrognosisProspective StudiesTomography, X-Ray ComputedCoronary artery diseaseCoronary atherosclerosisCoronary heart diseaseCoronary imagingCT angiographyMyocardial perfusion imaging

Identifiers

PMID34024757
PMCPMC8570979
OpenAlexW3160952166

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.