Evidence map›Paper›PMID 34024629›Full record

ArticleAmerican journal of surgery2021

Comparing intraoperative parathyroid identification based on surgeon experience versus near infrared autofluorescence detection - A surgeon-blinded multi-centric study.

Giju Thomas, Carmen C Solórzano, Naira Baregamian, Emmanuel A Mannoh, Rekha Gautam, Rebecca T Irlmeier, Fei Ye, Jon A Nelson, Samuel E Long, Paul G Gauger and 5 more

Registry-linked trialAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05152927 (Evaluating Impact of Near Infrared Autofluorescence), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05152927 nacompletednot on this mapstarted 2022, after this paper: background citation

Evaluating Impact of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy

TypeinterventionalSponsorUniversity of California, San FranciscoRan2022 to 2024Enrolled79ConditionsParathyroid Diseases, Parathyroid Dysfunction, Parathyroid Neoplasms, Parathyroid AdenomaArmsParathyroid Eye (PTeye)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Year in Thyroidology: Surgical Science.Thyroid : official journal of the American Thyroid Association · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giju ThomasVanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37235, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Carmen C SolórzanoDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Naira BaregamianDivision of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Emmanuel A MannohVanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37235, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Rekha GautamVanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37235, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA.
Rebecca T IrlmeierDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Fei YeDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, 37203, USA.
Jon A NelsonDivision of Endocrine Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Samuel E LongDepartment of General Surgery, Austin Regional Clinic South 1st, Austin, TX, 78704, USA.
Paul G GaugerDivision of Endocrine Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Alexa MagnerWest Virginia University School of Medicine, Morgantown, WV, 26506, USA.
Tyler MetcalfDivision of Surgical Oncology, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Lawrence A ShirleyLexington Surgical Specialists, Lexington, KY, 40503, USA.
John E PhayDivision of Surgical Oncology, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH, 43210, USA.
Anita Mahadevan-JansenVanderbilt Biophotonics Center, Vanderbilt University, Nashville, TN, 37235, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA. Electronic address: anita.mahadevan-jansen@vanderbilt.edu.

Funding

Academic-Industry Partnership for the Translation of a Novel Optical Imaging Approach to guide Endocrine Cancer SurgeryR01CA212147 · NCI · VANDERBILT UNIVERSITY · PI MAHADEVAN-JANSEN, ANITA · 2018 to 2022
$2.7M
NCI NIH HHS R01 CA212147
6 · The paper itself

Abstract

backgroundNear infrared autofluorescence (NIRAF) detection has previously demonstrated significant potential for real-time parathyroid gland identification. However, the performance of a NIRAF detection device - PTeye® - remains to be evaluated relative to a surgeon's own ability to identify parathyroid glands.

methodsPatients eligible for thyroidectomy and/or parathyroidectomy were enrolled under 6 endocrine surgeons at 3 high-volume institutions. Participating surgeons were categorized based on years of experience. All surgeons were blinded to output of PTeye® when identifying tissues. The surgeon's performance for parathyroid discrimination was then compared with PTeye®. Histology served as gold standard for excised specimens, while expert surgeon's opinion was used to validate in-situ tissues.

resultsPTeye® achieved 92.7% accuracy across 167 patients recruited. Junior surgeons (<5 years of experience) were found to have lower confidence in parathyroid identification and higher tissue misclassification rate per specimen when compared to PTeye® and senior surgeons (>10 years of experience).

conclusionsNIRAF detection with PTeye® can be a valuable intraoperative adjunct technology to aid in parathyroid identification for surgeons.

Indexed as

Intraoperative PeriodAdultAgedAged, 80 and overClinical CompetenceFemaleHumansMaleMiddle AgedOptical ImagingParathyroid GlandsSpectroscopy, Near-InfraredYoung AdultNear infrared autofluorescenceParathyroidectomyParathyroid glandsSurgical guidanceThyroidectomy

Identifiers

PMID34024629
PMCPMC8589928

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.