Evidence map›Paper›PMID 34024451›Full record

ReviewGastroenterology clinics of North America2021

Post-infection Irritable Bowel Syndrome.

Antonio Berumen, Adam L Edwinson, Madhusudan Grover

Abstract readReview
In one paragraph

Review in Gastroenterology clinics of North America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Trial
  2. Review
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  5. Article
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  11. Review
  12. Review
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  15. Article
  16. Leaky Gut Syndrome: Myths and Management.Gastroenterology & hepatology · 2024
    Article
  17. Article
  18. Can diet change the natural history of gastrointestinal diseases?JGH open : an open access journal of gastroenterology and hepatology · 2024
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Antonio BerumenDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Adam L EdwinsonDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
Madhusudan GroverDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA; Department of Medicine and Physiology, Enteric NeuroScience Program, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: grover.madhusudan@mayo.edu.

Funding

"Barrier function alterations in post-infectious irritable bowel syndrome"K23DK103911 · NIDDK · MAYO CLINIC ROCHESTER · PI GROVER, MADHUSUDAN · 2015 to 2019
$804k
Mechanisms of barrier dysfunction in post-infection irritable bowel syndromeR03DK120745 · NIDDK · MAYO CLINIC ROCHESTER · PI GROVER, MADHUSUDAN · 2019 to 2020
$239k
NIDDK NIH HHS K23 DK103911NIDDK NIH HHS R03 DK120745
6 · The paper itself

Abstract

Epidemiologic data support that acute gastrointestinal infection is one of the strongest risk factors for development of irritable bowel syndrome (IBS). Risk of post-infection IBS (PI-IBS) seems to be greater with bacterial and protozoal than viral enterocolitis. Younger individuals, women, and those with severe enterocolitis are more likely to develop PI-IBS. Disease mechanisms in animal models and humans involve chronic perturbation of intestinal microbiome, epithelial and neuronal remodeling, and immune activation. These mechanisms can lead to luminal (increased proteolytic activity, altered bile acid composition) and physiologic (increased permeability, transit changes, and visceral hypersensitivity) alterations that can mediate PI-IBS symptoms.

Indexed as

Gastrointestinal MicrobiomeInfectionsIrritable Bowel SyndromeAnimalsFemaleHumansBacteriaBarrier functionDiarrheaGut-brain axisInfectious gastroenteritisInflammationMicrobiome

Identifiers

PMID34024451
PMCPMC8144546

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.