Evidence map›Paper›PMID 34024178›Full record

ArticleInternational journal of immunopathology and pharmacology

MicroRNA-425 induces apoptosis and suppresses migration and invasion of human cervical cancer cells by targeting RAB2B.

Yue Tian, Ying Luo, Jing Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yue TianDelivery Room, Linyi Central Hospital, Linyi, Shandong Province, China.ORCID https://orcid.org/0000-0003-0673-4980
Ying LuoDelivery Room, Linyi Central Hospital, Linyi, Shandong Province, China.
Jing WangDepartment of Obstetrics, Linyi Central Hospital, Shangdong Province, China.
Linyi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulation of microRNA-425 (miR-425) has been reported in several human cancers. However, the role of miR-425 in human cervical cancer via modulation of RAB2B expression is still unclear. This study was therefore designed to examine the expression and decipher the role of miR-425 in cervical cancer. The qRT-PCR was used for expression analysis. MTT and EdU assays were used for the determination of cell viability and proliferation, respectively. Annexin V/PI staining was used to detect apoptosis. Wound healing and transwell assays were used to monitor cell migration and invasion. Western blotting was used for protein expression analysis. The

Indexed as

MicroRNAsUterine Cervical NeoplasmsAnimalsApoptosisCell Line, TumorCell MovementCell SurvivalFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMiceMice, Inbred BALB CMice, NudeMiddle AgedNeoplasm InvasivenessMicroRNAsMIRN425 microRNA, humanrab2b protein, mouserab2 GTP-Binding Proteinapoptosiscervical cancermetastasismicro-RNARAB2Bxenograft mice

Identifiers

PMID34024178
PMCPMC8150419
OpenAlexW3164281117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.