Evidence map›Paper›PMID 34024121›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

Mutagenesis of the Cleavage Site of Pro Renin Receptor Abrogates Angiotensin II-Induced Hypertension in Mice.

Fei Wang, Yanting Chen, Chang-Jiang Zou, Renfei Luo, Tianxin Yang

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. The soluble (pro)renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  3. Article
  4. Functional Roles of Furin in Cardio-Cerebrovascular Diseases.ACS pharmacology & translational science · 2024
    Review
  5. Review
  6. The (pro)renin receptor as a pharmacological target in cardiorenal diseaes.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Fei Wang *Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, United States.
Yanting Chen *Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, United States.
Chang-Jiang ZouDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, United States.
Renfei LuoDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, United States.
Tianxin YangDepartment of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, United States.
University of Utah · US

Funding

Interaction of PGE2 and intrarenal RAS in AngII-induced hypertensionR01DK104072 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2015 to 2025
$3.7M
Role of (pro)renin receptor in aldosterone signaling in the kidneyR01HL139689 · NHLBI · UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2018 to 2021
$2.3M
Interaction of (pro)renin receptor and PPARy in regulation of plasma volumeR01HL135851 · NHLBI · UNIVERSITY OF UTAH · PI YANG, TIANXIN · 2017 to 2021
$2.3M
Role of CTRP1 in Renal Sodium Handling in Obesity-Related HypertensionK99HL155850 · NHLBI · UNIVERSITY OF UTAH · PI WANG, FEI · 2021 to 2022
$180k
BLRD VA I01 BX004871BLRD VA IK6 BX005223NHLBI NIH HHS K99 HL155850NHLBI NIH HHS R01 HL135851NHLBI NIH HHS R01 HL139689NIDDK NIH HHS R01 DK104072
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Angiotensin IIAnimalsBase SequenceBinding SitesBlood PressureCells, CulturedCRISPR-Cas SystemsHypertensionMiceMice, KnockoutMutagenesisProtein PrecursorsReceptors, Cell SurfaceReninRenin-Angiotensin SystemAngiotensin IIProtein PrecursorsReceptors, Cell SurfaceReninangiotensin IIhypertensionrenin-angiotensin system site-1 proteasesoluble (pro)renin receptor

Identifiers

PMID34024121
PMCPMC9212214
OpenAlexW3164151832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.