Evidence map›Paper›PMID 34024117›Full record

ReviewStroke2021

2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association.

Dawn O Kleindorfer, Amytis Towfighi, Seemant Chaturvedi, Kevin M Cockroft, Jose Gutierrez, Debbie Lombardi-Hill, Hooman Kamel, Walter N Kernan, Steven J Kittner, Enrique C Leira and 9 more

Erratum issued 15 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 15 registered trials, which are not on this map. Cited by 1,616 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,616citing papers in PubMed, 13 pooled it
295.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06604117 recruitingstarted 2024, after this paper: background citation

A Prospective, Open-label Study Evaluating the Effects of Probucol Combined with Statins on Atherosclerotic Characteristics and Prognosis in Patients with Ischemic Stroke

Ran2024Enrolled200Registered outcomes6Posted comparisons0ConditionsAtherosclerosis of Artery, Ischemic Stroke, Lipid Disorder, StatinArmsProbucol, Statin
Open the trial in the graph
NCT06649240 narecruitingstarted 2024, after this paper: background citation

Optimal Target Low-density Lipoprotein Cholesterol Level for Small Vessel Occlusion Stroke (SVO70)

Ran2024Enrolled4,016Registered outcomes7Posted comparisons0ConditionsCardiovascular Diseases, Cholesterol, LDL, Ischemic Stroke, Secondary PreventionArmsPCSK9 inhibitor, Statins and/or Ezetimibe
Open the trial in the graph
NCT05461976 nacompletednot on this mapstarted 2022, after this paper: background citation

A Randomized, Controlled Pilot Study of a Home-based Self-management Exercise Program for Sedentary Individuals With Mild Disability After Stroke

TypeinterventionalSponsorFederal University of Minas GeraisRan2022 to 2023Enrolled24ConditionsStrokeArmsHome-based self-management exercise program
NCT05794399 phase4recruitingnot on this mapstarted 2023, after this paper: background citation

Comparison of Warfarin Versus Rivaroxaban in Management of Post-myocardial Infarction Left Ventricular Thrombus in a Tertiary Cardiac Center of Nepal: a Randomized Control Study.

TypeinterventionalSponsorShahid Gangalal National Heart CentreRan2023 to 2026Enrolled196ConditionsLeft Ventricular Thrombus, Myocardial InfarctionArmsRivaroxaban, Warfarin
NCT05907694 narecruitingnot on this mapstarted 2024, after this paper: background citation

Medical Treatment With or Without Transcatheter Patent Foramen Ovale CloSure for Older Patients With CrypTogenic StrOke and Patent Foramen Ovale. The STOP Trial

TypeinterventionalSponsorJosep Rodes-CabauRan2024 to 2037Enrolled714ConditionsPatent Foramen Ovale, Cryptogenic Stroke, Older Patients, Medical TreatmentArmsTranscatheter PFO closure, Optimal medical treatment
NCT05980195 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Cognitive Improvement After cARotid stEnting in HyperBaric Oxygen Therapy Trial (CARE-HBOT)

TypeinterventionalSponsorBeijing Tiantan HospitalRan2024 to 2025Enrolled90ConditionsCarotid Stenosis, Cognitive Impairment, Hyperbaric Oxygen Therapy, Stent ImplantationArmsHyperbaric oxygen therapy, Standard medical treatment, Risk factor management
NCT05995600 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Clopidogrel-based Antiplatelet Therapy Versus Warfarin As Secondary Prevention Strategy for AntiPhospholipid Syndrome-related STROKE (APS-STROKE)

TypeinterventionalSponsorSeoul National University HospitalRan2024 to 2029Enrolled200ConditionsAntiphospholipid Syndrome, Ischemic Stroke, Transient Ischemic Attack, Cerebrovascular DiseaseArmsAntiplatelet Drug, Warfarin
NCT06068036 narecruitingnot on this mapstarted 2023, after this paper: background citation

Telehealth Intervention Involving the HEARTS Technical Package and the Use of an Activity Monitor to Increase Physical Activity Level Post-stroke: a Feasibility Randomized Controlled Trial

TypeinterventionalSponsorFederal University of Minas GeraisRan2023 to 2025Enrolled24ConditionsStrokeArmsTelehealth intervention: HEARTS technical package + activity monitor (Smartwatch Mi Band 7®), Telehealth intervention: HEARTS technical package
NCT06255145 nacompletednot on this map

Assessment of Body Composition, Fatigue, Mobility and Functional Status in Post-Stroke Individuals

TypeinterventionalSponsorPamukkale UniversityRan2021 to 2022Enrolled42ConditionsCerebrovascular Stroke, Body CompositionArmsBioelectrical Impedance Analysis
NCT06767657 narecruitingnot on this mapstarted 2025, after this paper: background citation

Multicenter, Open-label Randomized Study Comparing Urgent Carotid Endarterectomy (CEA) (Within 72 Hours) Versus Delayed CEA (After 72 Hours) in Patients With Symptomatic Carotid Stenosis (SPREAD-STACI II)

TypeinterventionalSponsorItalian Society of Vascular and Endovascular SurgeryRan2025 to 2028Enrolled456ConditionsStroke, Ischemic, Transient Ischemic Accident, Endarterectomy, Carotid, Stroke PreventionArmsCEA (carotid endarterectomy)
NCT07224178 recruitingnot on this mapstarted 2025, after this paper: background citation

Left Atrial Strain: A Biomarker for Cryptogenic Stroke Prevention

TypeobservationalSponsorUniversity of PittsburghRan2025 to 2027Enrolled900ConditionsIschemic Stroke, Cryptogenic, Ischemic Stroke, Embolic, Hemorrhagic Stroke, Embolic Stroke of Undetermined Source
NCT07295769 narecruitingnot on this mapstarted 2026, after this paper: background citation

Atrial Fibrillation Detection Using MEMO Patch in Patients With Stroke of Unknown Cause: A Single-Center, Prospective, Exploratory Trial to Validate the Efficacy and Safety of Noninvasive Long-Term Electrocardiographic Monitoring

TypeinterventionalSponsorAsan Medical CenterRan2026 to 2029Enrolled100ConditionsEmbolic Stroke of Undetermined SourceArmsMEMO Patch M and MEMO Patch2
NCT07414732 narecruitingnot on this mapstarted 2026, after this paper: background citation

The "Savvy for Stroke Survivors" Study: Testing a Novel Tool to Help Stroke Survivors Take Their Medication

TypeinterventionalSponsorMassachusetts General HospitalRan2026 to 2027Enrolled150ConditionsStroke, Intracerebral Haemorrhage, Ischemic Stroke, TIA (Transient Ischemic Attack)ArmsSavvy Medication Adherence Intervention
NCT07421973 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

The UTRAVERA: a Multicenter Prospective Observational Investigation on Vertigo and Dizziness Due to Vertebrobasilar Transient Neurological Attacks - Diagnoses, Clinical Features, Treatment Responses, and Prognostic Factors.

TypeobservationalSponsorUniversity of Sao Paulo General HospitalRan2026 to 2028Enrolled400ConditionsVertigo, Dizziness, TIA (Transient Ischemic Attack), Transient Neurologic Symptoms
NCT07687706 phase3recruitingnot on this mapstarted 2026, after this paper: background citation

A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter, Superiority, Investigator-initiated Trial of Tegoprazan for Prevention of Gastrointestinal Complication in Ischemic Stroke Patients on Antiplatelet Therapy (TegoStroke)

TypeinterventionalSponsorHanyang University Guri HospitalRan2026 to 2027Enrolled1,524ConditionsIschemic Stroke, Ischemic Stroke, Acute, Transient Ischemic Attack (TIA), Cerebrovascular DiseaseArmsTegoprazan 50 mg, Placebo
3 · Its place in the literature

Who cites it

1,616 citing papers in PubMed, 13 syntheses or guidelines pooled it, 2,829 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Outcomes of patent foramen ovale closure in patients over 60 years with cryptogenic stroke: A systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2026
    Pooled it
  8. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Guideline
  9. Pooled it
  10. Patent foramen ovale closure versus medical therapy alone in elderly patients with cryptogenic stroke: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
  11. Management of brain-heart multimorbidity: a clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026
    Guideline
  12. Pooled it
  13. Interaction of CYP2C19 with the effect of clopidogrel in secondary prevention of major ischemic events: Systematic review and meta-analysis.International journal of stroke : official journal of the International Stroke Society · 2026
    Pooled it
  14. Trial
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  20. Trial

1,556 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Dawn O Kleindorfer
Amytis Towfighi
Seemant Chaturvedi
Kevin M Cockroft
Jose Gutierrez
Debbie Lombardi-Hill
Hooman Kamel
Walter N Kernan
Steven J Kittner
Enrique C Leira
Olive Lennon
James F Meschia
Thanh N Nguyen
Peter M Pollak
Pasquale Santangeli
Anjail Z Sharrief
Sidney C Smith
Tanya N Turan
Linda S Williams
Pasquali Macchine Agricole (Italy) · ITStaton (Slovakia) · SKTuran University · KZUniversity of Maryland Rehabilitation & Orthopaedic Institute · USVince Lombardi Cancer Clinic · USWilliams & Associates · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

American Heart AssociationClinical Decision-MakingHumansIschemic Attack, TransientPractice Guidelines as TopicRisk Reduction BehaviorStrokeUnited StatesAHA Scientific Statementsischemic attack, transientsecondary preventionstroke

Identifiers

PMID34024117
OpenAlexW3164908038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 9 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.