ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022
The effect of treatment and coping on the quality of life in breast cancer patients: a moderated mediation model.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Mediating the role of medical coping styles among psychosocial factors in breast cancer patients with type C personality.Scientific reports · 2026Article
- Impact of public vs. private insurance coverage on quality of life of women with early-stage estrogen receptor-positive breast cancer.Breast cancer research and treatment · 2025Article
- Coping Strategies and Health-Related Quality of Life in Breast Cancer Survivors.European journal of investigation in health, psychology and education · 2025Article
- Coping skills and associated sociodemographic, clinical, and psychological factors among women with breast cancer in Iraq: a cross-sectional study".BMC public health · 2025Article
- Quality of Life and Coping Strategies of Palestinian Women with Breast Cancer in the West Bank: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Social support and self-compassion mediate the relationship between alexithymia and quality of life in postoperative breast cancer patients: a cross-sectional study.Frontiers in psychology · 2025Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBreast cancer involves complicated emotional processes. One of the factors that impacts the psychological symptoms and decreases QoL is the side effects of treatment. The purpose of this study is to explore the effect of the main medical treatment (chemotherapy or hormone therapy) on the three domains of quality of life. For this, coping strategies were considered as psychological variables that mediate the relationship based on high or low alexithymia as a moderating variable.
methodsThis study had a cross-sectional design. The participant sample comprised 129 women with breast cancer in early stage (I to III) (63 receiving chemotherapy and 66 hormone therapy) and were evaluated from September 2015 to September 2019. Physical, emotional and social functioning were measured by the Quality of Life Questionnaire for cancer patients (EORTC-QLQ-C30), coping strategies were measured by Mental Adjustment to Cancer Questionnaire (MAC) and alexithymia was evaluated by the Alexithymia Toronto Scale (TAS-20).
resultsTreatment had a significant negative effect on physical domain in both patients receiving chemotherapy and hormone therapy. Moderated mediation analysis show that this relationship was significant when it was mediated by helplessness. Furthermore, this model is only significant when there are high levels of alexithymia. No significant effect direct was found on emotional and social functioning of quality of life.
conclusionsResults confirmed that coping based on helplessness and stable emotional variables such as alexithymia can have an effect, mediator or moderator, respectively, in the decrease of the physical functionality of women with breast cancer. Our findings highlight the need to include psychological therapy to help patients alleviate their psychological state because it can affect their physical condition.
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