ArticleClinical oral investigations2022
Interaction of periodontitis and orthodontic tooth movement-an in vitro and in vivo study.
Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Powered vs. manual toothbrushes in fixed orthodontic patients: a systematic review and meta-analysis.European journal of orthodontics · 2026Pooled it
- In vitro effects of tensile strain on cancer-associated and matched normal fibroblasts derived from oral squamous cell carcinoma: an exploratory study.BMC cancer · 2026Article
- Evaluating large language models for orthodontic consultation in patients with periodontitis: a study of reliability, quality, and readability.BMC oral health · 2026Article
- Timosaponin B- II Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells via PI3K/AKT/GSK3β Signaling Pathway.Stem cell reviews and reports · 2025Article
- Effect of Surface Wettability and Energy on Bacterial Adhesion to Dental Aligners: A Comparative In Vitro Study.Bioengineering (Basel, Switzerland) · 2025Article
- Article
- Effects of orthodontic tooth movement on periodontal tissues after ligature-induced periodontitis through the mechanism of RANKL-induced osteoclastogenesis: an animal study.BMC oral health · 2025Article
- The Role of Cytokines in Orthodontic Tooth Movement.International journal of molecular sciences · 2025Review
- Autophagy in orthodontic tooth movement: advances, challenges, and future perspectives.Molecular medicine (Cambridge, Mass.) · 2025Review
- Impact of mechanotransduction on gene expression changes in periodontal ligament during orthodontic tooth movement.Journal of bone and mineral metabolism · 2025Article
- Effect and mechanism of Sanqi () in treating periodontitis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- The effect of type 2 diabetes on periapical osteoclast-related factors during axial tooth movement.Frontiers in endocrinology · 2025Article
- Inflammation and mechanical force-induced bone remodeling.Periodontology 2000 · 2024Review
- Investigation of Oxidative-Stress Impact on Human Osteoblasts During Orthodontic Tooth Movement Using an In Vitro Tension Model.International journal of molecular sciences · 2024Article
- Article
- Effect of fence tray matching care on excess adhesive and bracket placement accuracy for orthodontic bonding: an in vitro study.BMC oral health · 2024Article
- Effect of the antirheumatic medication methotrexate (MTX) on biomechanical compressed human periodontal ligament fibroblasts (hPDLFs).BMC oral health · 2024Article
- Beneficial effects of non-invasive physical plasma on human periodontal ligament cellsFrontiers in medicine · 2024Article
- Non-Invasive Physical Plasma Reduces the Inflammatory Response in Microbially Prestimulated Human Gingival Fibroblasts.International journal of molecular sciences · 2023Article
- Mechanical force application and inflammation induce osteoclastogenesis by independent pathways.Clinical oral investigations · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
objectivesThe aim of this in vitro and in vivo study was to investigate the interaction of periodontitis and orthodontic tooth movement on interleukin (IL)-6 and C-X-C motif chemokine 2 (CXCL2). MATERIALS AND
methodsThe effect of periodontitis and/or orthodontic tooth movement (OTM) on alveolar bone and gingival IL-6 and CXCL2 expressions was studied in rats by histology and RT-PCR, respectively. The animals were assigned to four groups (control, periodontitis, OTM, and combination of periodontitis and OTM). The IL-6 and CXCL2 levels were also studied in human gingival biopsies from periodontally healthy and periodontitis subjects by RT-PCR and immunohistochemistry. Additionally, the synthesis of IL-6 and CXCL2 in response to the periodontopathogen Fusobacterium nucleatum and/or mechanical strain was studied in periodontal fibroblasts by RT-PCR and ELISA.
resultsPeriodontitis caused an increase in gingival levels of IL-6 and CXCL2 in the animal model. Moreover, orthodontic tooth movement further enhanced the bacteria-induced periodontal destruction and gingival IL-6 gene expression. Elevated IL-6 and CXCL2 gingival levels were also found in human periodontitis. Furthermore, mechanical strain increased the stimulatory effect of F. nucleatum on IL-6 protein in vitro.
conclusionsOur study suggests that orthodontic tooth movement can enhance bacteria-induced periodontal inflammation and thus destruction and that IL-6 may play a pivotal role in this process. CLINICAL RELEVANCE: Orthodontic tooth movement should only be performed after periodontal therapy. In case of periodontitis relapse, orthodontic therapy should be suspended until the periodontal inflammation has been successfully treated and thus the periodontal disease is controlled again.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.