Evidence map›Paper›PMID 34023986›Full record

ArticleMolecular biology reports2021

Metabolite fingerprinting, in vitro antimicrobial and antioxidant activities and in-silico docking in Alloteropsis cimicina and its endophytic fungus Penicillium pinophilum.

R Nischitha, M B Shivanna

Abstract read
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In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Phyto-and myco-chemical profiling, bioactivity, and in silico docking study of endophytic fungi and host-Setaria flavida.International microbiology : the official journal of the Spanish Society for Microbiology · 2025
    Article
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  4. Article
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

R NischithaDepartment of PG Studies and Research in Botany, School of Biosciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shivamogga, Karnataka, 577 451, India.
M B ShivannaDepartment of PG Studies and Research in Botany, School of Biosciences, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shivamogga, Karnataka, 577 451, India. mbshivanna@yahoo.co.uk.ORCID http://orcid.org/0000-0001-5308-2917

Funding

ALTERNATIVE PATHWAYS OF T CELL ACTIVATIONK08AR002017 · NIAMS · VANDERBILT UNIVERSITY · PI BYRD, VICTOR M · 1998 to 2002
$348k
University Grants Commission RGNF-2017-18-SC-KAR-38457
6 · The paper itself

Abstract

Endophytic fungal interaction with medicinal plant resulting in the production of bioactive compounds influenced the present study. Endophytic fungus Penicillium pinophilum Hedgc. from Alloteropsis cimicina with high incidence was isolated by incubation methods and characterized by morphological and molecular (ITS rDNA region) methods. Penicillium pinophilum was cultured on PD broth and metabolites of host and endophyte were extracted with ethyl acetate and methanol. Metabolites were assayed for antimicrobial potential by well diffusion and scavenging ability by spectrophotometric and electrochemical methods. Metabolite profiling by Orbitrap High-Resolution Liquid Chromatography-Mass Spectrometry and Fourier-transform infrared spectroscopy and by validation of antimicrobial and antioxidant activities in-silico drug-likeness of spectral compound prediction and molecular docking were performed. Host and P. pinophilum extracts showed strong antimicrobial potential against certain clinical bacterial strains and Fusarium oxysporum. Fungal extracts exhibited higher antioxidant activity than A. cimicina extract. Metabolite profiling indicated 14 and 21 antimicrobial, 10 and 13 antioxidant compounds in A. cimicina and P. pinophilum extracts, respectively. There were eight spectral compounds common to endophyte and host with high binding affinity towards receptors. The present study revealed that P. pinophilum and A. cimicina are natural reservoirs of novel bioactive compounds with antimicrobial and antioxidant properties.

Indexed as

Anti-Bacterial AgentsAntioxidantsEndophytesMass SpectrometryMolecular Docking SimulationPenicilliumPoaceaeAnti-Bacterial AgentsAntioxidantsCyclic voltammetryDrug likeness predictionMass spectroscopyMolecular dockingRadical scavenging assaysWell diffusion assay

Identifiers

PMID34023986

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.