ArticleNucleic acids research2021
MyCLADE: a multi-source domain annotation server for sequence functional exploration.
Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- From functional annotation to functional meaning in microbiome research.Environmental microbiome · 2026Review
- A UG5 reverse transcriptase-nitrilase antiviral module confers phage immunity in the plant symbiontMicrobiology spectrum · 2026Article
- Pangenomic and functional domain comparison of enterotoxigenic Escherichia coli isolated from humans and swine: insights into host specificity.Molecular genetics and genomics : MGG · 2026Article
- Scaling the profile of life by function with SPIN.Bioinformatics advances · 2026Article
- Fidelity, specialization, and evolution of Paramecium PolX DNA polymerases involved in programmed double-strand break DNA repair.Nucleic acids research · 2025Article
- Protists and protistology in the Anthropocene: challenges for a climate and ecological crisis.BMC biology · 2024Review
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Authors and funding
4 authors.
Funding
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Abstract
The ever-increasing number of genomic and metagenomic sequences accumulating in our databases requires accurate approaches to explore their content against specific domain targets. MyCLADE is a user-friendly webserver designed for targeted functional profiling of genomic and metagenomic sequences based on a database of a few million probabilistic models of Pfam domains. It uses the MetaCLADE multi-source domain annotation strategy, modelling domains based on multiple probabilistic profiles. MyCLADE takes a list of protein sequences and possibly a target set of domains/clans as input and, for each sequence, it provides a domain architecture built from the targeted domains or from all Pfam domains. It is linked to the Pfam and QuickGO databases in multiple ways for easy retrieval of domain and clan information. E-value, bit-score, domain-dependent probability scores and logos representing the match of the model with the sequence are provided to help the user to assess the quality of each annotation. Availability and implementation: MyCLADE is freely available at http://www.lcqb.upmc.fr/myclade.
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Registered trials
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