Evidence map›Paper›PMID 34023345›Full record

ArticleThe Journal of pediatrics2021

Late Diagnosis of Congenital Toxoplasmosis with Macrocephaly in Dizygotic Twins after Incidental Detection of Leukocoria: A Case Report.

Coralee Del Valle Mojica, Jose G Montoya, Jennifer McGuire, Krisha L Palma, Karuna V Shekdar, Rima McLeod, Despina G Contopoulos-Ioannidis

Open access · greenAbstract readCase Reports
In one paragraph

Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Coralee Del Valle MojicaDivision of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Jose G MontoyaDr Jack S. Remington Laboratory for Specialty Diagnostics, National Reference Center for the Study and Diagnosis of Toxoplasmosis Palo Alto Medical Foundation, Palo Alto, CA.
Jennifer McGuireDivision of Neurology, Department of Neurology and Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Krisha L PalmaDepartment of Specialty Pharmacy, Children's Hospital of Philadelphia, Philadelphia, PA.
Karuna V ShekdarDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA.
Rima McLeodToxoplasmosis Center and Research Institute, National Collaborative Chicago-based-Toxoplasmosis Study (NCCCTS), Departments of Ophthalmology and Visual Sciences, and Pediatric (Infectious Diseases, Global Health Center, Center for Health and The Social Sciences (CHeSS), Committee on Immunology, Institute of Genomics, Genetics and Systems Biology, The College, Chicago Medicine, The University of Chicago, Chicago, IL.
Despina G Contopoulos-IoannidisDepartment of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA.
Children's Hospital of Philadelphia · USStanford University · USUniversity of Chicago · US

Funding

Altered Brain Structure and Function in Adolescents with Behaviorally Acquired HIVK23NS094069 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI MCGUIRE, JENNIFER L · 2016 to 2020
$904k
NINDS NIH HHS K23 NS094069
6 · The paper itself

Abstract

Untreated congenital toxoplasmosis remains an important cause of neurologic and ocular disease worldwide. However, congenitally infected infants may not have signs and symptoms their physicians recognize, leading to delayed diagnosis and missed opportunities for treatment. We describe a pair of twins diagnosed with congenital toxoplasmosis at 11 months of age following incidental detection of leukocoria in one twin.

Indexed as

Delayed DiagnosisFemaleHumansIncidental FindingsInfantMaleMegalencephalyPupil DisordersToxoplasmosis, CongenitalTwins, Dizygoticcongenital toxoplasmosishydrocephalusleukocoriamacrocephalypyrimethaminesulfadiazine allergyTORCH

Identifiers

PMID34023345
PMCPMC9642312
OpenAlexW3162943148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.