Observational studyCritical care (London, England)2021
Mechanical circulatory support for refractory out-of-hospital cardiac arrest: a Danish nationwide multicenter study.
Observational study in Critical care (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 75 citations in OpenAlex.
- Extracorporeal versus conventional cardiopulmonary resuscitation for refractory out-of-hospital cardiac arrest: a secondary analysis of the Prague OHCA trial.Critical care (London, England) · 2022Trial
- Ethics in prehospital extracorporeal cardiopulmonary resuscitation.Resuscitation plus · 2026Article
- Applying randomized control trial criteria to an ECPR cohort.Resuscitation plus · 2026Article
- Centralization of post-resuscitation care after out-of-hospital cardiac arrest at cardiac arrest centres: a Danish nationwide follow-up study.Critical care (London, England) · 2026Article
- Clinical characteristics of patients with cardiogenic shock after out-of-hospital cardiac arrest (OHCA) compared to patients with cardiogenic shock without OHCA.Cardiology journal · 2026Article
- Eligibility for Extracorporeal Cardio-Pulmonary Resuscitation in Out-of-Hospital Cardiac Arrests in Sweden.Acta anaesthesiologica Scandinavica · 2026Article
- The Pre-ECPR score for predicting favorable neurological outcomes after extracorporeal cardiopulmonary resuscitation: protocol for external validation in the Prague OHCA trial cohort.Resuscitation plus · 2026Article
- Impact of extended eligibility criteria on survival after veno-arterial extracorporeal membrane oxygenation for refractory cardiac arrest: a 8-year single-center study.Resuscitation plus · 2025Article
- Article
- Clinical Prediction Score for Patients With Initial Nonshockable Rhythm Receiving Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest: Development and Internal Validation.Journal of the American Heart Association · 2025Observational
- Comparative analysis of inflammatory response on post resuscitation syndrome in extracorporeal cardiopulmonary resuscitation.Resuscitation plus · 2025Article
- Intestinal fatty acid-binding protein as a marker of prognosis and non-occlusive mesenteric ischemia in refractory cardiac arrest patients: a pilot study.Resuscitation plus · 2025Article
- Different strategies in left ventricle unloading during venoarterial extracorporeal membrane oxygenation: A network meta-analysis.International journal of cardiology. Heart & vasculature · 2024Review
- Association of hyperfibrinolysis with poor prognosis in refractory circulatory arrest: implications for extracorporeal cardiopulmonary resuscitation.British journal of anaesthesia · 2024Article
- ECPR-the evolving role in cardiac arrest.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Review
- Implementation of an extracorporeal resuscitation (ECPR) program for out-of-hospital cardiac arrest in Stockholm, Sweden: Feasibility, safety, and outcome.Resuscitation plus · 2024Article
- Extracorporeal cardiopulmonary resuscitation for patients with refractory out-of-hospital cardiac arrest: a propensity score matching, observational study.Scientific reports · 2024Observational
- Return to Work After Refractory Out-of-Hospital Cardiac Arrest in Patients Managed With or Without Extracorporeal Cardiopulmonary Resuscitation: A Nationwide Register-Based Study.Journal of the American Heart Association · 2024Article
- Prognostic value of arterial carbon dioxide tension during cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients receiving extracorporeal resuscitation.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024Article
- Factors associated with favourable neurological outcomes following cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A retrospective multi-centre cohort study.Resuscitation plus · 2024Article
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundMechanical circulatory support (MCS) with either extracorporeal membrane oxygenation or Impella has shown potential as a salvage therapy for patients with refractory out-of-hospital cardiac arrest (OHCA). The objective of this study was to describe the gradual implementation, survival and adherence to the national consensus with respect to use of MCS for OHCA in Denmark, and to identify factors associated with outcome.
methodsThis retrospective, observational cohort study included patients receiving MCS for OHCA at all tertiary cardiac arrest centers (n = 4) in Denmark between July 2011 and December 2020. Logistic regression and Kaplan-Meier survival analysis were used to determine association with outcome. Outcome was presented as survival to hospital discharge with good neurological outcome, 30-day survival and predictors of 30-day mortality.
resultsA total of 259 patients were included in the study. Thirty-day survival was 26%. Sixty-five (25%) survived to hospital discharge and a good neurological outcome (Glasgow-Pittsburgh Cerebral Performance Categories 1-2) was observed in 94% of these patients. Strict adherence to the national consensus showed a 30-day survival rate of 30% compared with 22% in patients violating one or more criteria. Adding criteria to the national consensus such as signs of life during cardiopulmonary resuscitation (CPR), pre-hospital low-flow < 100 min, pH > 6.8 and lactate < 15 mmol/L increased the survival rate to 48%, but would exclude 58% of the survivors from the current cohort. Logistic regression identified asystole (RR 1.36, 95% CI 1.18-1.57), pulseless electrical activity (RR 1.20, 95% CI 1.03-1.41), initial pH < 6.8 (RR 1.28, 95% CI 1.12-1.46) and lactate levels > 15 mmol/L (RR 1.16, 95% CI 1.16-1.53) as factors associated with increased risk of 30-day mortality. Patients presenting signs of life during CPR had reduced risk of 30-day mortality (RR 0.63, 95% CI 0.52-0.76).
conclusionsA high survival rate with a good neurological outcome was observed in this Danish population of patients treated with MCS for OHCA. Stringent patient selection for MCS may produce higher survival rates but potentially withholds life-saving treatment in a significant proportion of survivors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.