Evidence map›Paper›PMID 34022911›Full record

ReviewCell communication and signaling : CCS2021

Types of nuclear localization signals and mechanisms of protein import into the nucleus.

Juane Lu, Tao Wu, Biao Zhang, Suke Liu, Wenjun Song, Jianjun Qiao, Haihua Ruan

Abstract readReview
In one paragraph

Review in Cell communication and signaling : CCS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 258 papers.

0numbers the graph read from it
0cells of the map it votes in
258citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

258 citing papers in PubMed.

  1. Review
  2. Article
  3. An ancient evolutionary origin for IL-1 cytokines.Nature ecology & evolution · 2026
    Article
  4. Review
  5. Building peroxisomes: perspectives on plant peroxins.Biochemical Society transactions · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Subcellular localization as a driver of protein function.Nature reviews. Molecular cell biology · 2026
    Review
  18. Article
  19. Review
  20. Article

198 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juane LuTianjin Key Laboratory of Food Science and Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Tao WuTianjin Key Laboratory of Food Science and Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Biao ZhangTianjin Key Laboratory of Food Science and Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Suke LiuTianjin Key Laboratory of Food Science and Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Wenjun SongTianjin Key Laboratory of Food Science and Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Jianjun QiaoKey Laboratory of Systems Bioengineering, Ministry of Education, Tianjin, China. jianjunq@tju.edu.cn.
Haihua RuanTianjin Key Laboratory of Food Science and Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China. ruanhaihua@tjcu.edu.cn.ORCID 0000-0003-2955-9791

Funding

Natural Science Foundation of Tianjin City 18JCYBJC96000the General Program of National Natural Science Foundation of China 31870122Youth Program of National Natural Science Foundation of China 21908168
6 · The paper itself

Abstract

Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition, a process necessary for cargo proteins to pass the nuclear envelope through the nuclear pore complex, is facilitated by members of the importin superfamily. Here, we summarized the types of NLS, focused on the recently reported related proteins containing nuclear localization signals, and briefly summarized some mechanisms that do not depend on nuclear localization signals into the nucleus. Video Abstract.

Indexed as

Amino Acid SequenceAnimalsCell NucleusHumansModels, BiologicalNuclear Localization SignalsProtein TransportNuclear Localization SignalsImportinNuclear localization signalNuclear pore complex

Identifiers

PMID34022911
PMCPMC8140498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.