Evidence map›Paper›PMID 34022844›Full record

ArticleBMC pulmonary medicine2021

Downregulation of the PD-1/PD-Ls pathway in peripheral cells correlates with asbestosis severity.

Meihua Qiu, Yuqing Chen, Qiao Ye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. PD-1/PD-L1 axis in organ fibrosis.Frontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Meihua Qiu *Department of Occupational Medicine and Toxicology, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Worker's Stadium, Chao-Yang District, Beijing, China.
Yuqing Chen *Department of Occupational Medicine and Toxicology, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Worker's Stadium, Chao-Yang District, Beijing, China.
Qiao YeDepartment of Occupational Medicine and Toxicology, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Worker's Stadium, Chao-Yang District, Beijing, China. yeqiao_chaoyang@sina.com.ORCID http://orcid.org/0000-0002-0932-0487
Capital Medical University · CN

Funding

Innovative Research Group Project of the National Natural Science Foundation of China No.81070046Innovative Research Group Project of the National Natural Science Foundation of China No.81970061Natural Science Foundation of Beijing Municipality (CN) No.7142058
6 · The paper itself

Abstract

backgroundAsbestosis and silicosis are characterized by diffuse or nodular interstitial lung fibrosis resulting from exposure to asbestos or silica dust, respectively. This study was designed to detect programmed cell death protein (PD-1)/programmed death ligands (PD-Ls) expression in patients with asbestosis and silicosis and to explore the possible clinical significance of PD-1/PD-Ls expression in patients with the two diseases.

methodsThirty patients with asbestosis, 23 patients with silicosis and 25 healthy controls were consecutively recruited and provided informed consent to participate in the study. Clinical data were collected from patients' clinical charts. PD-1/PD-Ls expression in peripheral blood (PB) was detected using flow cytometry.

resultsPD-1 was expressed at significantly lower levels on CD4

conclusionsDecreased PD-1 expression on CD4

Indexed as

AdultAgedAged, 80 and overAsbestosisB7-H1 AntigenCase-Control StudiesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDown-RegulationFemaleHumansLeukocytes, MononuclearMaleMiddle AgedProgrammed Cell Death 1 Ligand 2 ProteinProgrammed Cell Death 1 ReceptorB7-H1 AntigenProgrammed Cell Death 1 Ligand 2 ProteinProgrammed Cell Death 1 ReceptorAsbestosisLung fibrosisLung functionPD-1PD-LsSilicosisT cell activation

Identifiers

PMID34022844
PMCPMC8141175
OpenAlexW3164080700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.