Evidence map›Paper›PMID 34022800›Full record

ArticleBMC gastroenterology2021

Low preoperative prealbumin predicts the prevalence of complications following liver transplantation.

Yuancheng Li, Xingchao Liu, Yan Jiang, Kun Wan, Wei Liu, Yanjiao Ou, Jie Bai, Yuemei You, Feng Hu, Zeliang Xu and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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  4. Usefulness of Retinol-Binding Protein in Predicting Mortality in Patients With Chronic Liver Disease.JGH open : an open access journal of gastroenterology and hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Yuancheng Li *College of Basic Medical Sciences, Third Military Medical University (Army Medical University), Chongqing, China.
Xingchao Liu *Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Sichuan, China.
Yan JiangDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), No. 30, Gaotanyan Road, Chongqing, 400038, China.
Kun WanDepartment of Medical Imagine, People's Liberation Army of China 949 Hospital, Xinjiang Military Hospital, Xinjiang, China.
Wei LiuDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), No. 30, Gaotanyan Road, Chongqing, 400038, China.
Yanjiao OuDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), No. 30, Gaotanyan Road, Chongqing, 400038, China.
Jie BaiDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), No. 30, Gaotanyan Road, Chongqing, 400038, China.
Yuemei YouDepartment of Surgery and Anesthesiology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Feng HuCollege of Basic Medical Sciences, Third Military Medical University (Army Medical University), Chongqing, China.
Zeliang XuCollege of Basic Medical Sciences, Third Military Medical University (Army Medical University), Chongqing, China.
Ping BieDepartment of Hepatopancreatobiliary Surgery, The Third Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Chengcheng ZhangDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), No. 30, Gaotanyan Road, Chongqing, 400038, China. zccszcg@163.com.
Leida ZhangDepartment of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), No. 30, Gaotanyan Road, Chongqing, 400038, China. zldxngd@163.com.
Southwest Hospital · CNArmy Medical University · CNChongqing Medical University · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs a nutritional index, preoperative serum prealbumin highly correlates with surgical complications. However, the correlation between preoperative prealbumin and postoperative complications remains unclear in liver transplantation (LT).

methodsA total of 191 patients who underwent LT between 2015 and 2019 were included in the retrospective analysis. According to a cut-off value calculated from a receiver operating characteristic (ROC) curve, the patients were divided into normal and low preoperative prealbumin groups. Univariable and multivariable logistic regression analyses were used to identify independent risk factors for postoperative complications. In addition, patients were divided into subgroups by Model for End-stage Liver Disease (MELD) score, and the association between preoperative prealbumin and postoperative complications was also assessed in each group.

resultsA total of 111 (58.1%) patients were included in the low prealbumin group based on a cut-off value of 120 mg/L. The area under the ROC curve (AUC) was 0.754 (95% confidence interval [CI] 0.678-0.832). Low prealbumin (95% CI 1.51-12.8, P = 0.007) was identified as a predictor for postoperative complications based on multivariable regression. In the low and normal prealbumin groups, the prevalence rates of postoperative complications were 27.5% and 8.0% (P = 0.003) in the MELD score ≤ 15 subgroup and 53.3% and 20.0% (P = 0.197) in the MELD score > 15 subgroup, respectively.

conclusionsPreoperative prealbumin was associated with postoperative complications in LT, and preoperative nutritional support benefitted postoperative recovery, especially for patients with low MELD scores.

Indexed as

End Stage Liver DiseaseLiver TransplantationHumansPrealbuminPrevalencePrognosisRetrospective StudiesROC CurveSeverity of Illness IndexPrealbuminLiver transplantationMELD subgroupsPostoperative complicationsPreoperative prealbumin

Identifiers

PMID34022800
PMCPMC8141182
OpenAlexW3164328261

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.