Evidence map›Paper›PMID 34022670›Full record

ArticleImmunobiology2021

Acquired decrease of the C3b/C4b receptor (CR1, CD35) and increased C4d deposits on erythrocytes from ICU COVID-19 patients.

Aymric Kisserli, Nathalie Schneider, Sandra Audonnet, Thierry Tabary, Antoine Goury, Joel Cousson, Rachid Mahmoudi, Firouze Bani-Sadr, Lukshe Kanagaratnam, Damien Jolly and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Immunobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  8. Immunoregulation role of the erythroid cells.Frontiers in immunology · 2024
    Review
  9. Article
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  11. Article
  12. Review
  13. The ultimate tradeoff: how red cell adaptations to malaria alter the host response during critical illness.American journal of physiology. Lung cellular and molecular physiology · 2023
    Review
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Aymric KisserliOncogeriatric Coordination Unit, Rheims University Hospital, Rheims, France; Nanosciences Research Laboratory LRN EA 4682, University of Rheims Champagne-Ardenne, Rheims, France.
Nathalie SchneiderBiochemistry, Pharmacology and Toxicology Unit, Rheims University Hospital, Rheims, France.
Sandra AudonnetURCACyt, Flow Cytometry Technical Platform, University of Rheims Champagne-Ardenne, Rheims, France.
Thierry TabaryNanosciences Research Laboratory LRN EA 4682, University of Rheims Champagne-Ardenne, Rheims, France; Immunology Laboratory, Rheims University Hospital, Rheims, France.
Antoine GouryMedical-Surgical ICU, Rheims University Hospital, Rheims, France.
Joel CoussonMedical-Surgical ICU, Rheims University Hospital, Rheims, France.
Rachid MahmoudiDepartment of Internal Medicine and Geriatrics, Rheims University Hospital, Rheims, France; Aging and Fragility Unit EA 3797, University of Rheims Champagne-Ardenne, Rheims, France.
Firouze Bani-SadrMedical-Surgical ICU, Rheims University Hospital, Rheims, France.
Lukshe KanagaratnamAging and Fragility Unit EA 3797, University of Rheims Champagne-Ardenne, Rheims, France; Research Promotion and Support Unit, Rheims University Hospital, Rheims, France.
Damien JollyAging and Fragility Unit EA 3797, University of Rheims Champagne-Ardenne, Rheims, France; Research Promotion and Support Unit, Rheims University Hospital, Rheims, France.
Jacques Hm CohenNanosciences Research Laboratory LRN EA 4682, University of Rheims Champagne-Ardenne, Rheims, France. Electronic address: jacques.cohen@univ-reims.fr.
Université de Reims Champagne-Ardenne · FRLaboratoire de Recherche en Nanosciences

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to study the mechanisms of COVID-19 damage following the complement activation phase occurring during the innate immune response to SARS-CoV-2, CR1 (the regulating complement activation factor, CD35, the C3b/C4b receptor), C4d deposits on Erythrocytes (E), and the products of complement activation C3b/C3bi, were assessed in 52 COVID-19 patients undergoing O

Indexed as

Antigen-Antibody ComplexComplement ActivationComplement C4bCOVID-19ErythrocytesFranceGene Expression RegulationHumansIntensive Care UnitsPeptide FragmentsReceptors, Complement 3bSARS-CoV-2Antigen-Antibody ComplexComplement C4bcomplement C4dCR1 protein, humanPeptide FragmentsReceptors, Complement 3bC3C4CD35ComplementCOVID-19CR1Erythrocytes

Identifiers

PMID34022670
PMCPMC8106962
OpenAlexW3161833030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.