Evidence map›Paper›PMID 34022622›Full record

ReviewEpilepsy & behavior : E&B2021

The baboon in epilepsy research: Revelations and challenges.

C Ákos Szabó, Felipe S Salinas

Open access · greenAbstract readReview
In one paragraph

Review in Epilepsy & behavior : E&B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

C Ákos SzabóDepartments of Neurology, UT Health San Antonio, San Antonio, TX, United States. Electronic address: szabo@uthscsa.edu.
Felipe S SalinasRadiology, UT Health San Antonio, San Antonio, TX, United States; Research Imaging Institute, UT Health San Antonio, San Antonio, TX, United States.
The University of Texas Health Science Center at Houston · USThe University of Texas Health Science Center at San Antonio · US

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
WNV REPLIVAX VACCINE IN NON-HUMAN PRIMATESP51RR013986 · NCRR · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI GAUDUIN, MARIE-CLAIRE ELISABETH · 1999 to 2011
$79.1M
Baboon Model for Genetics of Human Generalized EpilepsyR01NS047755 · NINDS · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI WILLIAMS, JEFF · 2004 to 2007
$1.1M
EXTRAMURAL RES FACILITIES CONSTRC06RR015456 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 2001 to 2001
$1.1M
Brain MRI and Histopathology of the Epileptic BaboonR21NS084198 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SZABO, CHARLES AKOS · 2014 to 2015
$411k
Multimodal Evaluation of Networks Underlying Photosensitive Epilepsy in BaboonsR21NS065431 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SZABO, CHARLES AKOS · 2009 to 2010
$408k
A Baboon Model of TMS/PET as a Vehicle for Rational Development of TMS TreatmentsR21NS062254 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2009 to 2010
$407k
Modeling the neuronal activations induced by transcranial magnetic stimulationF32NS066694 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SALINAS, FELIPE SANTIAGO · 2010 to 2011
$108k
BABOON F-CAGE FACILITY FOR PRIMATE RESEARCH CENTERC06RR014578 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI VANDEBERG, JOHN L · 1999 to 1999
–
MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATIONC06RR013556 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 1998 to 1998
–
NCRR NIH HHS C06 RR013556NCRR NIH HHS C06 RR014578NCRR NIH HHS C06 RR015456NCRR NIH HHS P51 RR013986NIH HHS P51 OD011133NINDS NIH HHS F32 NS066694NINDS NIH HHS R01 NS047755NINDS NIH HHS R21 NS062254NINDS NIH HHS R21 NS065431NINDS NIH HHS R21 NS084198
6 · The paper itself

Abstract

The baboon offers a natural model for genetic generalized epilepsy with photosensitivity. In this review, we will summarize some of the more important clinical, neuroimaging, and elctrophysiological findings form recent work performed at the Southwest National Primate Research Center (SNPRC, Texas Biomedical Research Institute, San Antonio, Texas), which houses the world's largest captive baboon pedigree. Due to the phylogenetic proximity of the baboon to humans, many of the findings are readily translatable, but there may be some important differences, such as the mutlifocality of the ictal and interictal epileptic discharges (IEDs) on intracranial electroencephalography (EEG) and greater parieto-occipital connectivity of baboon brain networks compared to juvenile myoclonic epilepsy in humans. Furthermore, there is still limited knowledge of the natural history of the epilepsy, which could be transformative for research into epileptogenesis in genetic generalized epilepsy (GGE) and sudden unexpected death in epilepsy (SUDEP).

Indexed as

ElectroencephalographyEpilepsy, GeneralizedAnimalsPapioPhylogenyTexasBaboonElectrophysiologyGenetic generalized epilepsyNeuroimagingNeurostimulationSeizure detection

Identifiers

PMID34022622
PMCPMC8238811
OpenAlexW3160268166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.