Evidence map›Paper›PMID 34022302›Full record

ArticleProgress in biophysics and molecular biology2022

Efficient metadata mining of web-accessible neural morphologies.

Masood A Akram, Bengt Ljungquist, Giorgio A Ascoli

Abstract read
In one paragraph

Article in Progress in biophysics and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Masood A AkramCenter for Neural Informatics, Structures & Plasticity, Krasnow Institute for Advanced Study, And Department of Bioengineering, Volgenau School of Engineering, George Mason University, Fairfax, 22030, VA, USA.
Bengt LjungquistCenter for Neural Informatics, Structures & Plasticity, Krasnow Institute for Advanced Study, And Department of Bioengineering, Volgenau School of Engineering, George Mason University, Fairfax, 22030, VA, USA.
Giorgio A AscoliCenter for Neural Informatics, Structures & Plasticity, Krasnow Institute for Advanced Study, And Department of Bioengineering, Volgenau School of Engineering, George Mason University, Fairfax, 22030, VA, USA. Electronic address: ascoli@gmu.edu.

Funding

Anatomical characterization of neuronal cell types of the mouse brainU01MH114829 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ASCOLI, GIORGIO A, DONG, HONG-WEI · 2017 to 2021
$13.9M
Generation and Description of Neuronal Morphology and ConnectivityR01NS039600 · NINDS · GEORGE MASON UNIVERSITY · PI ASCOLI, GIORGIO A · 1999 to 2024
$6.9M
Cytoskeletal mechanisms of dendrite arbor shape developmentR01NS086082 · NINDS · GEORGIA STATE UNIVERSITY · PI ASCOLI, GIORGIO A, COX, DANIEL N · 2013 to 2023
$3.1M
NIMH NIH HHS U01 MH114829NINDS NIH HHS R01 NS039600NINDS NIH HHS R01 NS086082
6 · The paper itself

Abstract

Advancements in neuroscience research have led to steadily accelerating data production and sharing. The online community repository of neural reconstructions NeuroMorpho.Org grew from fewer than 1000 digitally traced neurons in 2006 to more than 140,000 cells today, including glia that now constitute 10.1% of the content. Every reconstruction consists of a detailed 3D representation of branch geometry and connectivity in a standardized format, from which a collection of morphometric features is extracted and stored. Moreover, each entry in the database is accompanied by rich metadata annotation describing the animal subject, anatomy, and experimental details. The rapid expansion of this resource in the past decade was accompanied by a parallel rise in the complexity of the available information, creating both opportunities and challenges for knowledge mining. Here, we introduce a new summary reporting functionality, allowing NeuroMorpho.Org users to efficiently download digests of metadata and morphometrics from multiple groups of similar cells for further analysis. We demonstrate the capabilities of the tool for both glia and neurons and present an illustrative statistical analysis of the resulting data.

Indexed as

MetadataNeurosciencesAnimalsDatabases, FactualNeuronsApplication programming interfaceDigital reconstructionsGliaMorphometryNeuroMorpho.OrgNeuronSummary reporting

Identifiers

PMID34022302
PMCPMC8602463

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.