ArticleAmerican journal of ophthalmology2021
Presence of SARS-CoV-2 Viral RNA in Aqueous Humor of Asymptomatic Individuals.
Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Quantification of Droplet Aerosol Generation During Phacoemulsification and Pars Plana Vitrectomy.Cureus · 2026Article
- Utility of Protein Markers in COVID-19 Patients.International journal of molecular sciences · 2025Review
- Acute angle-closure glaucoma before, during, and after the outbreak of COVID-19 in China.Heliyon · 2024Article
- Article
- SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure.PLoS pathogens · 2024Article
- Topical Application of Cell-Penetrating Peptide Modified Anti-VEGF Drug Alleviated Choroidal Neovascularization in Mice.International journal of nanomedicine · 2024Article
- Considerations of COVID-19 in Ophthalmology.Microorganisms · 2023Review
- Long-Term Decrease in Intraocular Pressure in Survivors of Ebola Virus Disease in the Partnership for Research on Vaccines and Infectious Diseases in Liberia (PREVAIL) III Study.Ophthalmology science · 2023Article
- Vaccine-Associated Uveitis after COVID-19 Vaccination: Vaccine Adverse Event Reporting System Database Analysis.Ophthalmology · 2023Article
- The Outbreak of Acute Primary Angle-Closure Cases During the COVID-19 Omicron Variant Pandemic at a Tertiary Eye Center in Shanghai.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- The occurrence of acute primary angle closure triggered, aggravated, and accelerated by COVID-19 infection: retrospective observational study.Frontiers in public health · 2023Observational
- Initial anterior uveitis event associated with recent novel SARS-CoV-2 (COVID-19) infection in the setting of HLA-B27.American journal of ophthalmology case reports · 2022Article
- Detection of SARS-CoV-2-RNA in post-mortem samples of human eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- Response to comments on: Evaluating the presence of SARS-CoV-2 in the intraocular fluid of COVID-19 patients.Indian journal of ophthalmology · 2022Article
- Review
- Changes in Anterior Chamber Parameters Measured by Pentacam in Coronavirus Disease 2019 Infection: A Longitudinal Study.Journal of ophthalmology · 2022Article
- Severe acute respiratory syndrome Corona virus and intraocular fluid sampling.Indian journal of ophthalmology · 2021Article
- Does ocular tissue contain SARS CoV-2?Indian journal of ophthalmology · 2021Article
- Manifestations of coronavirus infection disease-19 in anterior eye segment: An up-to-date review.Oman journal of ophthalmologyReview
- COVID-19 and ocular complications: A review of ocular manifestations, diagnostic tools, and prevention strategies.Advances in ophthalmology practice and researchReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is detectable in the aqueous of asymptomatic individuals presenting for ophthalmic surgery.
designProspective cross-sectional study.
methodsSetting and participants: all patients undergoing anterior segment surgery at an ambulatory surgical center (ASC) belonging to a tertiary academic center in South Florida during a 102-day period between June and September 2020 received nasal swab testing for SARS-CoV-2 and underwent a relevant review of symptoms prior to surgery, with negative results required for both in order to proceed with surgery. Main outcomes and measurements: a small sample of aqueous humor (approximately 0.2 cc) was acquired at the beginning of anterior segment surgery from all participants. Aqueous humor was analyzed for SARS-CoV-2 viral ribonucleic acid (RNA) using real-time reverse transcriptase polymerase chain reaction. Demographic information was acquired from participants for secondary analyses.
resultsA total of 70 samples were acquired. Of those, 39 samples were excluded due to insufficient material or inconclusive results. Of 31 samples that were successfully analyzed, 6 (19.4%) demonstrated detectable SARS-CoV-2 RNA. None of the 6 individuals (0%) with detectable viral RNA in aqueous humor reported symptoms during the year, compared to 2 of 25 individuals (8%) with negative samples (P = 1). Positive samples were distributed throughout the study period, including both the first and the last days of enrollment.
conclusionsThe presence of SARS-CoV-2 viral RNA in aqueous despite negative nasal swab testing confirmed its presence beyond the blood-ocular barrier in asymptomatic individuals and raises the possibility that the virus may persist in immunoprivileged spaces despite an absence of symptoms.
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