ArticleThe Journal of biological chemistry
Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling.
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Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Non-canonical cleavage of GPR125/ADGRA3 releases extracellular receptor fragments detectable in cerebrospinal fluid.iScience · 2026Article
- The therapeutic potential of orphan adhesion G-protein-coupled receptors.Nature reviews. Drug discovery · 2026Review
- Purinergic signaling promotes gliomagenesis through nuclear calcium transients.bioRxiv : the preprint server for biology · 2026Article
- Adhesion G protein-coupled receptors.Pharmacological reviews · 2026Review
- Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors.Nature communications · 2026Article
- ADGRD1 promotes bladder cancer progression and angiogenesis via the PI3K/AKT/mTOR-mediated pro-angiogenic secretome.Frontiers in oncology · 2026Article
- Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors.Nature communications · 2025Article
- Domain-specific N-glycosylation of the adhesion G-protein-coupled receptor ADGRG6 N-terminal fragment regulates trafficking, proteolytic processing, and signaling.Molecular biology of the cell · 2025Article
- Generic residue numbering of the GAIN domain of adhesion GPCRs.Nature communications · 2025Article
- Upregulation ofEpigenetics · 2024Article
- Modulation of GPR133 (ADGRD1) signaling by its intracellular interaction partner extended synaptotagmin 1.Cell reports · 2024Article
- Mechanistic Insights into Peptide Binding and Deactivation of an Adhesion G Protein-Coupled Receptor.Molecules (Basel, Switzerland) · 2023Article
- The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.Cell reports · 2023Article
- Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs.Nano letters · 2023Article
- PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma.Cell reports · 2023Article
- Article
- Adhesion G protein-coupled receptors: structure, signaling, physiology, and pathophysiology.Physiological reviews · 2022Review
- Activation of the adhesion G protein-coupled receptor GPR133 by antibodies targeting its N-terminus.The Journal of biological chemistry · 2022Article
- Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 3 countries.
Joshua D FrensterDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA; Kimmel Center for Stem Cell Biology, NYU Grossman School of Medicine, New York, New York, USA.
Gabriele StephanDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA.
Niklas Ravn-BoessDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA.
Devin BreadyDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA.
Jordan WilcoxDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA.
Bjoern KieslichInstitute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany.
Caroline WildeMedical Faculty, Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Leipzig, Germany.
Norbert SträterInstitute of Bioanalytical Chemistry, Center for Biotechnology and Biomedicine, University of Leipzig, Leipzig, Germany.
Giselle R WigginHeptares Therapeutics Ltd, Cambridge, UK.
Ines LiebscherMedical Faculty, Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Leipzig, Germany.
Torsten SchönebergMedical Faculty, Rudolf Schönheimer Institute of Biochemistry, University of Leipzig, Leipzig, Germany.
Dimitris G PlacantonakisDepartment of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA; Kimmel Center for Stem Cell Biology, NYU Grossman School of Medicine, New York, New York, USA; Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, New York, USA; Brain and Spine Tumor Center, NYU Grossman School of Medicine, New York, New York, USA; Neuroscience Institute, NYU Grossman School of Medicine, New York, New York, USA. Electronic address: dimitris.placantonakis@nyulangone.org.
Leipzig University · DENew York University · USHeptares Therapeutics (United Kingdom) · GBNYU Langone’s Laura and Isaac Perlmutter Cancer Center
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1MTraining Program in Cell BiologyT32GM136542 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMITH, SUSAN · 2020 to 2024
$3.0MThe role of GPR133 in glioblastomaR01NS102665 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PLACANTONAKIS, DIMITRIS G. · 2018 to 2022
$2.3MFingerprinting-Based Neuronal Fiber Identification in Brain SurgeryR01EB028774 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BAETE, STEVEN H. · 2020 to 2023
$1.9MNCI NIH HHS P30 CA016087NIBIB NIH HHS R01 EB028774NIGMS NIH HHS T32 GM136542NINDS NIH HHS R01 NS102665
Abstract
GPR133 (ADGRD1), an adhesion G protein-coupled receptor (GPCR) whose canonical signaling activates G
Indexed as
Signal TransductionCyclic AMPGlioblastomaHumansProteolysisReceptors, G-Protein-CoupledTumor Cells, CulturedADGRD1 protein, humanCyclic AMPReceptors, G-Protein-Coupledadhesion GPCRglioblastomaglycosylationintracellular traffickingintramolecular cleavageNTF–CTF dissociationreceptor structure–functionsignalingsubcellular fractionation
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.