Evidence map›Paper›PMID 34022145›Full record

ArticleThe Lancet. Planetary health2021

City-level vulnerability to temperature-related mortality in the USA and future projections: a geographically clustered meta-regression.

Claire R Lay, Marcus C Sarofim, Alina Vodonos Zilberg, Dave M Mills, Russell W Jones, Joel Schwartz, Patrick L Kinney

Abstract read
In one paragraph

Article in The Lancet. Planetary health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  4. Quantifying the contributions of climate change and adaptation to mortality from unprecedented extreme heat events.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  13. Nocturnal heat exposure and stroke risk.European heart journal · 2024
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  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Claire R LayAbt Associates, Boulder, CO, USA.
Marcus C SarofimUS Environmental Protection Agency, Washington, DC, USA. Electronic address: sarofim.marcus@epa.gov.
Alina Vodonos ZilbergHarvard School of Public Health, Boston, MA, USA.
Dave M MillsPeak to Peak Economics, Boulder, CO, USA.
Russell W JonesAbt Associates, Boulder, CO, USA.
Joel SchwartzHarvard School of Public Health, Boston, MA, USA.
Patrick L KinneyBoston University School of Public Health, Boston, MA, USA.

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

backgroundExtreme heat exposure can lead to premature death. Climate change is expected to increase the frequency, intensity, and duration of extreme heat events, resulting in many additional heat-related deaths globally, as well as changing the nature of extreme cold events. At the same time, vulnerability to extreme heat has decreased over time, probably due to a combination of physiological, behavioural, infrastructural, and technological adaptations. We aimed to account for these changes in vulnerability and avoid overstated projections for temperature-related mortality. We used the historical observed decrease in vulnerability to improve future mortality estimates.

methodsWe used historical mortality and temperature data from 208 US cities to quantify how observed changes in vulnerability from 1973 to 2013 affected projections of temperature-related mortality under various climate scenarios. We used geographically structured meta-regression to characterise the relationship between temperature and mortality for these urban populations over the specified time period. We then used the fitted relationships to project mortality under future climate conditions.

findingsBetween Oct 26, 2018, and March 9, 2020, we established that differences in vulnerability to temperature were geographically structured. Vulnerability decreased over time in most areas. US mortalities projected from a 2°C increase in mean temperature decreased by more than 97% when using 2003-13 data compared with 1973-82 data. However, these benefits declined with increasing temperatures, with a 6°C increase showing only an 84% decline in projected mortality based on 2003-13 data.

interpretationEven after accounting for adaptation, the projected effects of climate change on premature mortality constitute a substantial public health risk. Our work suggests large increases in temperature will require additional mitigation to avoid excess mortality from heat events, even in areas with high air conditioning coverage in place.

fundingThe US Environmental Protection Agency and Abt Associates.

Indexed as

Climate ChangeExtreme HeatCitiesHot TemperatureHumansTemperatureUnited States

Identifiers

PMID34022145
PMCPMC9422466

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.