Evidence map›Paper›PMID 34021836›Full record

ArticleJournal of molecular modeling2021

Electronic structure and reactivity of tirapazamine as a radiosensitizer.

José Romero, Thana Maihom, Paulo Limão-Vieira, Michael Probst

Open access · hybridAbstract read
In one paragraph

Article in Journal of molecular modeling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

José RomeroInstitute of Ion Physics and Applied Physics, University of Innsbruck, Technikerstraße 25, 6020, Innsbruck, Austria. j.romero@campus.fct.unl.pt.
Thana MaihomSchool of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology, Rayong, 21210, Thailand.
Paulo Limão-VieiraAtomic and Molecular Collisions Laboratory, CEFITEC, Department of Physics, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal. plimaovieira@fct.unl.pt.ORCID http://orcid.org/0000-0003-2696-1152
Michael ProbstInstitute of Ion Physics and Applied Physics, University of Innsbruck, Technikerstraße 25, 6020, Innsbruck, Austria. michael.probst@uibk.ac.at.ORCID http://orcid.org/0000-0003-3112-5597
Universität Innsbruck · ATUniversidade Nova de Lisboa · PTVidyasirimedhi Institute of Science and Technology · TH

Funding

FCT - Fundação para a Ciência e a Tecnologia (PT) PD/BD/142846/2018FCT - Fundação para a Ciência e a Tecnologia (PT) PTDC/FIS-AQM/31281/2017FCT - Fundação para a Ciência e a Tecnologia (PT) UIDB/00068/2020
6 · The paper itself

Abstract

Tirapazamine (TP) has been shown to enhance the cytotoxic effects of ionizing radiation in hypoxic cells, thus making it a candidate for a radiosensitizer. This selective behavior is often directly linked to the abundance of O

Indexed as

Models, ChemicalModels, MolecularRadiation-Sensitizing AgentsTirapazamineRadiation-Sensitizing AgentsTirapazamineCancerDensity functional theoryHypoxiaRadiationRadiosensitizerTirapazamine

Identifiers

PMID34021836
PMCPMC8140980
OpenAlexW3161741489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.