Evidence map›Paper›PMID 34021690›Full record

ArticleCellular microbiology2021

The type III secretion system effector EspO of enterohaemorrhagic Escherichia coli inhibits apoptosis through an interaction with HAX-1.

Sharanya Chatterjee, Sujinna Lekmeechai, Nicolas Constantinou, Ewa A Grzybowska, Zuzanna Kozik, Jyoti S Choudhary, Cedric N Berger, Gad Frankel, Abigail Clements

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Attaching and effacing pathogens modulate host mitochondrial structure and function.International review of cell and molecular biology · 2023
    Review
  4. Impact of Epithelial Cell Shedding on Intestinal Homeostasis.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Sharanya ChatterjeeDepartment of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College, London, UK.ORCID 0000-0002-5806-6278
Sujinna LekmeechaiDepartment of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College, London, UK.
Nicolas ConstantinouDepartment of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College, London, UK.
Ewa A GrzybowskaDepartment of Molecular and Translational Oncology, Maria Sklodowska-Curie National Institute of Oncology, Warsaw, Poland.
Zuzanna KozikFunctional Proteomics Group, The Institute for Cancer Research, London, UK.
Jyoti S ChoudharyFunctional Proteomics Group, The Institute for Cancer Research, London, UK.
Cedric N BergerDepartment of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College, London, UK.
Gad FrankelDepartment of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College, London, UK.ORCID 0000-0002-0046-1363
Abigail ClementsDepartment of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College, London, UK.ORCID 0000-0003-2285-777X
Imperial College London · GBInstitute of Cancer Research · GBNational Institute of Oncology · HU

Funding

Biotechnology and Biological Sciences Research CouncilMedical Research Council MR/K019007/1Medical Research Council MR/R020671/1Wellcome Trust
6 · The paper itself

Abstract

Many enteric pathogens employ a type III secretion system (T3SS) to translocate effector proteins directly into the host cell cytoplasm, where they subvert signalling pathways of the intestinal epithelium. Here, we report that the anti-apoptotic regulator HS1-associated protein X1 (HAX-1) is an interaction partner of the T3SS effectors EspO of enterohaemorrhagic Escherichia coli (EHEC) and Citrobacter rodentium, OspE of Shigella flexneri and Osp1

Indexed as

Enterohemorrhagic Escherichia coliEnteropathogenic Escherichia coliEscherichia coli ProteinsApoptosisCitrobacter rodentiumType III Secretion SystemsEscherichia coli ProteinsType III Secretion Systemsinfectionmechanism of actionmicrobial-cell interactionvirulence

Identifiers

PMID34021690
PMCPMC7613270
OpenAlexW3161174377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.