Evidence map›Paper›PMID 34021607›Full record

Trial reportJournal of clinical pharmacology2021

Biperiden Challenge Model in Healthy Elderly as Proof-of-Pharmacology Tool: A Randomized, Placebo-Controlled Trial.

Charlotte Bakker, Michiel J van Esdonk, Rik F E Stuurman, Laura G J M Borghans, Marieke L de Kam, Joop M A van Gerven, Geert Jan Groeneveld

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Charlotte BakkerCentre for Human Drug Research, Leiden, The Netherlands.
Michiel J van EsdonkCentre for Human Drug Research, Leiden, The Netherlands.
Rik F E StuurmanCentre for Human Drug Research, Leiden, The Netherlands.ORCID 0000-0002-0013-8355
Laura G J M BorghansCentre for Human Drug Research, Leiden, The Netherlands.ORCID 0000-0001-5580-1153
Marieke L de KamCentre for Human Drug Research, Leiden, The Netherlands.
Joop M A van GervenCentre for Human Drug Research, Leiden, The Netherlands.
Geert Jan GroeneveldCentre for Human Drug Research, Leiden, The Netherlands.
Centre for Human Drug Research · NLLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective M

Indexed as

AgedAttentionBiperidenCognitionCross-Over StudiesDose-Response Relationship, DrugDouble-Blind MethodFemaleHealthy VolunteersHumansMaleMuscarinic AntagonistsReaction TimeBiperidenMuscarinic AntagonistsacetylcholinebiperidencognitionM1 receptorpharmacokineticspharmacology

Identifiers

PMID34021607
PMCPMC8596596
OpenAlexW3163095126

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.