Evidence map›Paper›PMID 34021521›Full record

ArticleClinical transplantation2021

A comparative study of human-and rhesus-specific antithymocyte globulins in Rhesus macaques.

Brian I Shaw, Robin Schmitz, Walter J Flores, Diogo M Magnani, Jie Li, Mingqing Song, Allan D Kirk

Open access · greenAbstract read
In one paragraph

Article in Clinical transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Brian I ShawDepartment of Surgery, Duke University, Durham, NC, USA.ORCID 0000-0002-2317-6549
Robin SchmitzDepartment of Surgery, Duke University, Durham, NC, USA.ORCID 0000-0003-1286-0457
Walter J FloresMassBiologics, University of Massachusetts Medical School, Boston, MA, USA.
Diogo M MagnaniMassBiologics, University of Massachusetts Medical School, Boston, MA, USA.
Jie LiDepartment of Surgery, Duke University, Durham, NC, USA.
Mingqing SongDepartment of Surgery, Duke University, Durham, NC, USA.
Allan D KirkDepartment of Surgery, Duke University, Durham, NC, USA.
Duke University · USUniversity of Massachusetts Chan Medical School · US

Funding

The Risks and Opportunities of Homeostatic RepopulationU19AI131471 · NIAID · DUKE UNIVERSITY · PI Andrew Serghios Barbas · 2017 to 2026
$30.4M
Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
Resource CoreP40OD028116 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2020 to 2026
$5.9M
National Institute of Allergy and Infectious Diseases U19AI131471National Institute of Allergy and Infectious Diseases U24AI126683NIAID NIH HHS U19 AI131471NIAID NIH HHS U24 AI126683NIH HHS P40 OD028116
6 · The paper itself

Abstract

Rabbit antithymocyte globulin (RATG) preparations are widely used in transplantation. They are developed in vivo against thymocytes and contain polyclonal antibodies specific for myriad cellular targets. The rhesus monkey is commonly used as a preclinical transplant model, but the fidelity of commercially available human-specific RATGs to anticipate the effects of RATGs in rhesus has not been established. We therefore developed two rhesus-specific ATGs (rhATG) and compared them to human-specific RATG (huATG, Thymoglobulin

Indexed as

Antilymphocyte SerumAnimalsFlow CytometryHumansMacaca mulattaAntilymphocyte SerumimmunosuppressantImmunosuppressantpolyclonal preparationspolyclonal preparations: rabbit antithymocyte globulinT cell biology

Identifiers

PMID34021521
PMCPMC8484028
OpenAlexW3161313818

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.