ArticleAnnals of nuclear medicine2021
Left-ventricular dyssynchrony in viable myocardium by myocardial perfusion SPECT is predictive of mechanical response to CRT.
Article in Annals of nuclear medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- A New Method of Modeling the Multi-stage Decision-Making Process of CRT Using Machine Learning with Uncertainty Quantification.Journal of imaging informatics in medicine · 2026Article
- Clinical phenotypes among patients that underwent cardiac resynchronization therapy using unsupervised learning integrating gated SPECT.Nuclear medicine communications · 2025Article
- A New Method Using Deep Learning to Predict the Response to Cardiac Resynchronization Therapy.Journal of imaging informatics in medicine · 2025Article
- Heart failure in China: epidemiology and current management.Journal of geriatric cardiology : JGC · 2024Article
- A machine learning method integrating ECG and gated SPECT for cardiac resynchronization therapy decision support.European journal of nuclear medicine and molecular imaging · 2023Article
- Left ventricular mechanical dyssnchrony: A potential new marker for 3-vessel CAD.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic and non-ischemic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A Mild Dyssynchronous Contraction Pattern Detected by SPECT Myocardial Perfusion Imaging Predicts Super-Response to Cardiac Resynchronization Therapy.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
objectivesGated myocardial perfusion SPECT (GMPS) provides a one-stop-shop evaluation for cardiac resynchronization therapy (CRT). However, conflicting results have been observed regarding whether the baseline left-ventricular (LV) mechanical dyssynchrony as assessed by phase analysis on GMPS was predictive of therapeutic response to CRT. Since dyssynchrony parameters by phase analysis spuriously increased by scarred myocardium, the purpose of this study was to explore the value of dyssynchrony after stripping off the scar region in correlation to mechanical response to CRT.
methodsForty-seven patients following standard indications for CRT received GMPS with phase analysis as pre-CRT evaluation. A decrease of end-systolic volume (ESV) > 15% on follow-up echocardiography after CRT was considered as a mechanical response to CRT. Myocardial regions with less than 50% of maximal activity on GMPS were considered as a scar. The phase standard deviation (PSD) and histogram bandwidth (BW) without or with stripping off scar were assessed by phase analysis of GMPS and were used for evaluation of LV dyssynchrony of all myocardium or only the viable myocardium, respectively.
resultsNo significant difference was noted between mechanical responders (31 of 47 patients, 66%) and nonresponders ( 16 of 47 patients, 34%) for PSD (48.6° ± 19.4° vs 43.9° ± 20.7°, p = 0.46) and BW (225° ± 91.1° vs 163.5° ± 94.6°, p = 0.38) of the entire myocardium. However, responders had significantly larger PSD (40.5° ± 15.7° vs 30.5° ± 13.2°, p = 0.03) and borderlinely larger BW (215° ± 91.2° vs. 139.5° ± 78.2°, p = 0.05) than non-responders after stripping off scar. Logistic regression analysis showed that scar area and PSD after stripping off scar were independent predictors of mechanical response.
conclusionsOur result showed that LV dyssynchrony of the entire myocardium did not predict response to CRT. However, LV dyssynchrony only in the viable myocardium was a significant predictor of CRT mechanical response.
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