SynthesisBrain imaging and behavior2022
Abnormal hemispheric asymmetry of both brain function and structure in attention deficit/hyperactivity disorder: a meta-analysis of individual participant data.
Synthesis in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Typical development of the human fetal subplate: Regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Temporal variability in pupillary asymmetry reflects ADHD-related traits in preschool and early school-aged children.Frontiers in cognition · 2026Article
- Attenuated rightward hemispheric asymmetry in ADHD: structural MRI evidence from a normalized asymmetry index and its association with cognitive performance.Frontiers in neuroscience · 2026Article
- Connectome-based symptom mapping and in silico related gene expression in children with autism and/or attention-deficit/hyperactivity disorder.Molecular psychiatry · 2026Article
- Typical development of the human fetal subplate: regional heterogeneity, growth, and asymmetry assessed by in vivo T2-weighted MRI.bioRxiv : the preprint server for biology · 2025Article
- Deep adversarial learning identifies ADHD-specific associations between apoptotic genes and white matter microstructure in frontal-striatum-cerebellum circuit.Translational psychiatry · 2025Article
- Effect of medication on the rostrolateral prefrontal oxygenation and thalamic volume asymmetry in youths with ADHD.Frontiers in integrative neuroscience · 2025Article
- Symptom-guided multimodal neuroimage fusion patterns in children with attention-deficit/hyperactivity disorder and its potential "brain structure-function-cognition-behavior" pathological pathways.European child & adolescent psychiatry · 2024Article
- Clinical implications of brain asymmetries.Nature reviews. Neurology · 2024Review
- Epigenome Defines Aberrant Brain Laterality in Major Mental Illnesses.Brain sciences · 2024Review
- Working Memory-Related Neurofunctional Correlates Associated with the Frontal Lobe in Children with Familial vs. Non-Familial Attention Deficit/Hyperactivity Disorder.Brain sciences · 2023Article
- Frequency characteristics of temporal and spatial concordance among dynamic indices in inattentive and combined subtypes of attention deficit hyperactivity disorder.Frontiers in neuroscience · 2023Article
- Brain laterality evaluated by F-18 fluorodeoxyglucose positron emission computed tomography in autism spectrum disorders.Frontiers in molecular neuroscience · 2022Article
- Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders.Frontiers in neurology · 2022Review
- Resting-State fMRI Whole Brain Network Function Plasticity Analysis in Attention Deficit Hyperactivity Disorder.Neural plasticity · 2022Article
- Asymmetry in the Central Nervous System: A Clinical Neuroscience Perspective.Frontiers in systems neuroscience · 2021Review
- Differential neural processing of value during decision-making in adults with attention-deficit/hyperactivity disorder and healthy controls.Journal of psychiatry & neuroscience : JPNArticle
- Voxel-based and surface-based morphometric analyses reveal cortical-subcortical structural abnormalities and cognitive correlates in drug-naïve SeLECTS.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
Aberration in the asymmetric nature of the human brain is associated with several mental disorders, including attention deficit/hyperactivity disorder (ADHD). In ADHD, these aberrations are thought to reflect key hemispheric differences in the functioning of attention, although the structural and functional bases of these defects are yet to be fully characterized. In this study, we applied a comprehensive meta-analysis to multimodal imaging datasets from 627 subjects (303 typically developing control [TDCs] and 324 patients with ADHD) with both resting-state functional and structural magnetic resonance imaging (MRI), from seven independent publicly available datasets of the ADHD-200 sample. We performed lateralization analysis and calculated the combined effects of ADHD on each of three cortical regional measures (grey matter volume - GMV, fractional amplitude of low frequency fluctuations at rest -fALFF, and regional homogeneity -ReHo). We found that compared with TDC, 68%,73% and 66% of regions showed statistically significant ADHD disorder effects on the asymmetry of GMV, fALFF, and ReHo, respectively, (false discovery rate corrected, q = 0.05). Forty-one percent (41%) of regions had both structural and functional abnormalities in asymmetry, located in the prefrontal, frontal, and subcortical cortices, and the cerebellum. Furthermore, brain asymmetry indices in these regions were higher in children with more severe ADHD symptoms, indicating a crucial pathoplastic role for asymmetry. Our findings highlight the functional asymmetry in ADHD which has (1) a strong structural basis, and thus is likely to be developmental in nature; and (2) is strongly linked to symptom burden and IQ and may carry a possible prognostic value for grading the severity of ADHD.
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