Evidence map›Paper›PMID 34021393›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2021

Feasibility of short imaging protocols for [

Mengmeng Song, Maximilian Scheifele, Henryk Barthel, Thilo van Eimeren, Leonie Beyer, Ken Marek, Florian Eckenweber, Carla Palleis, Lena Kaiser, Anika Finze and 29 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Dynamic [Molecular neurodegeneration · 2026
    Article
  3. Article
  4. Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  5. Review
  6. A Biomarker-Based Classification of Corticobasal Syndrome.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  7. Developing a novel reference region for [European journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Exploring the origins of frequent tau-PET signal in vermal and adjacent regions.European journal of nuclear medicine and molecular imaging · 2025
    Article
  9. Kinetic modeling ofEJNMMI research · 2025
    Article
  10. Article
  11. Article
  12. Reproducibility of [EJNMMI physics · 2024
    Article
  13. Assessment of [European journal of nuclear medicine and molecular imaging · 2024
    Article
  14. Tau accumulation is associated with dopamine deficiency in vivo in four-repeat tauopathies.European journal of nuclear medicine and molecular imaging · 2024
    Article
  15. One-Year Longitudinal Changes in Tau Accumulation on [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors at 8 institutions in 4 countries.

Mengmeng Song *Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Maximilian Scheifele *Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Henryk BarthelDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Thilo van EimerenCognitive Neuroscience, Institute for Neuroscience and Medicine (INM-3), Research Centre Juelich, Juelich, Germany.
Leonie BeyerDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Ken MarekInviCRO, LLC, Boston, MA, USA.
Florian EckenweberDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Carla PalleisDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Lena KaiserDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Anika FinzeDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Maike KernDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Alexander NitschmannDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Gloria BiecheleDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Sabrina KatzdoblerDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Gèrard BischofDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
Jochen HammesDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
Frank JessenGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Dorothee SaurDepartment of Neurology, University Hospital Leipzig, Leipzig, Germany.
Matthias L SchroeterDepartment of Neurology, University Hospital Leipzig, Leipzig, Germany.
Jost-Julian RumpfDepartment of Neurology, University Hospital Leipzig, Leipzig, Germany.
Michael RullmannDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Andreas SchildanDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Marianne PattDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Bernd NeumaierInstitute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, Jülich, Germany.
Andrew W StephensLife Molecular Imaging GmbH, Berlin, Germany.
Boris-Stephan RauchmannDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Robert PerneczkyDepartment of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Johannes LevinDepartment of Neurology, University Hospital of Munich, LMU Munich, Munich, Germany.
Joseph ClassenDepartment of Neurology, University Hospital Leipzig, Leipzig, Germany.
Günter U HöglingerDepartment of Psychiatry, University Hospital Cologne, Cologne, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Guido BoeningDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Sibylle ZieglerDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany.
Victor VillemagneDepartment of Molecular Imaging & Therapy, Austin Health, Heidelberg, VIC, Australia.
Alexander DrzezgaDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
John SeibylInviCRO, LLC, Boston, MA, USA.
Osama SabriDepartment of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
Matthias BrendelDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, Marchioninstraße 15, 81377, Munich, Germany. matthias.brendel@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-9247-2843
German Imaging Initiative for Tauopathies (GII4T)
LMU Klinikum · DEUniversity Hospital Leipzig · DEGerman Center for Neurodegenerative Diseases · DEForschungszentrum Jülich · DEInvicro (United States) · USKlinik und Poliklinik für Nuklearmedizin · DEThe University of Melbourne · AUUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [

methodsThirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. [

results0-50 and 0-40 DVR showed equivalent effect sizes as 0-60 DVR (averaged Cohen's d: 1.22 and 1.16 vs. 1.26), whereas the performance dropped for 0-30 or 0-20 DVR. The 20-40 SUVr indicated the best performance of all static acquisition windows (averaged Cohen's d: 0.99). The globus pallidus internus discriminated patients with PSP-RS and HCs at a similarly high level for 0-60 DVR (AUC: 0.96), 0-40 DVR (AUC: 0.96), and 20-40 SUVr (AUC: 0.94). The multi-region classifier sensitivity of these time windows was consistently 86%.

conclusionTruncated and static imaging windows can be used for [

Indexed as

Alzheimer DiseaseSupranuclear Palsy, ProgressiveFeasibility StudiesHumansPositron-Emission Tomographytau Proteinstau Proteins[18F]PI-2620Progressive supranuclear palsyTau-PETTime window

Identifiers

PMID34021393
PMCPMC8484138
OpenAlexW3127331590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.