Evidence map›Paper›PMID 34021358›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2021

Electrochemical skin conductance by Sudoscan®: a new tool to predict intradialytic hypotension.

Pauline Reach, Maxime Touzot, Yannis Lombardi, Catherine Maheas, Emmanuelle Sacco, Audrey Fels, Hélène Beaussier, Pablo Ureña-Torres, Gilles Chatellier, Christophe Ridel and 1 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03990142 (Study of Abnormalities of the Vegetative Nervous System in the Occurrence of Intradialytic Arterial Hypotension), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03990142 nacompletednot on this map

Study of Abnormalities of the Vegetative Nervous System in the Occurrence of Intradialytic Arterial Hypotension

TypeinterventionalSponsorFondation Hôpital Saint-JosephRan2019 to 2021Enrolled176ConditionsHemodialysis ComplicationArmsCutaneous conductance to chlorine by SUDOSCAN
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Pauline ReachService de Neurologie, Groupe Hospitalier Saint-Joseph, Paris, France.
Maxime TouzotAURA Paris Plaisance, Dialyse et Aphérèse Thérapeutique, Paris, France.
Yannis LombardiAURA Paris Plaisance, Dialyse et Aphérèse Thérapeutique, Paris, France.
Catherine MaheasAURA Paris Plaisance, Dialyse et Aphérèse Thérapeutique, Paris, France.
Emmanuelle SaccoCentre de Recherche Clinique, Groupe Hospitalier Saint-Joseph, Paris, France.
Audrey FelsCentre de Recherche Clinique, Groupe Hospitalier Saint-Joseph, Paris, France.
Hélène BeaussierCentre de Recherche Clinique, Groupe Hospitalier Saint-Joseph, Paris, France.
Pablo Ureña-TorresAURA Saint-Ouen Dialyse, Saint-Ouen, France.
Gilles ChatellierCIC 1418, Hôpital Européen Georges Pompidou Paris, Paris, France.
Christophe RidelAURA Paris Plaisance, Dialyse et Aphérèse Thérapeutique, Paris, France.
Mathieu ZuberService de Neurologie, Groupe Hospitalier Saint-Joseph, Paris, France.
Association pour l'Utilisation du Rein Artificiel · FRHôpital Paris Saint-Joseph · FRDélégation Paris 5 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntradialytic hypotension (IDH), a common complication in haemodialysis (HD) patients, is associated with multiple risk factors including cardiac dysfunction and alterations of the peripheral autonomic nervous system. To what extent dysautonomia may contribute to the occurrence of IDH remains elusive. We sought to investigate the clinical utility of Sudocan®, a device that quantifies dysautonomia, in the prediction of IDH.

methodsWe conducted a prospective monocentric study in adult HD patients from July 2019 to February 2020. Dysautonomia was assessed by the measurements of hand and foot electrochemical skin conductance (ESC) using Sudocan®, before HD. The primary endpoint was the incidence of IDH (The National Kidney Foundation/Kidney-Dialysis Outcome Quality Initiative definition), according to the presence of a pathological hand and/or foot ESC value, during the 3-month study period.

resultsA total of 176 HD patients (64 ± 14 years old) were enrolled. Mean pre-dialysis HD hand and foot ESC was 45 ± 20 and 54 ± 22 µS, respectively. About 35% and 40% of patients had a pathological ESC at the hand and foot, respectively. IDH occurred in 46 patients. Logistic regression showed that pathologic pre-dialysis HD hand ESC was associated with an increased risk of IDH [odds ratio = 2.56, 95% CI (1.04-6.67), P = 0.04]. The cumulative risk incidence of IHD during the study was 5.65 [95% CI (2.04-15.71), P = 0.001] and 3.71 [95% CI (1.41-9.76), P = 0.008], with a pathological hand and foot ESC, respectively.

conclusionsA pathological hand ESC, as assessed by a non-invasive Sudoscan® test, is associated with an increased risk of IDH.

Indexed as

HypotensionKidney Failure, ChronicAdultAgedHumansMiddle AgedProspective StudiesRenal DialysisRisk Factorsdialysiselectrochemical skin conductanceintra-dialytic hypotensionSudoscan®

Identifiers

PMID34021358
PMCPMC8311574
OpenAlexW3163784843

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.