Evidence map›Paper›PMID 34021316›Full record

ArticleCardiovascular research2021

Does the cardioprotective effect of Empagliflozin involve inhibition of the sodium-proton exchanger?

Elizabeth Murphy, David A Eisner

Abstract readEditorialComment
In one paragraph

Article in Cardiovascular research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Ion channel trafficking implications in heart failure.Frontiers in cardiovascular medicine · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Elizabeth MurphyNational Heart, Lung and Blood Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-9400-0797
David A EisnerUnit of Cardiac Physiology Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.ORCID 0000-0002-7002-3748

Funding

Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZIAHL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2009 to 2025
$20.4M
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ProtonsSodiumBenzhydryl CompoundsGlucosidesBenzhydryl CompoundsempagliflozinGlucosidesProtonsSodium

Identifiers

PMID34021316
PMCPMC8848318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.