Evidence map›Paper›PMID 34021274›Full record

ReviewNature reviews. Neuroscience2021

Cannabis and synaptic reprogramming of the developing brain.

Anissa Bara, Jacqueline-Marie N Ferland, Gregory Rompala, Henrietta Szutorisz, Yasmin L Hurd

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
21.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 200 citations in OpenAlex.

  1. Acute effects of different types of cannabis on young adult and adolescent resting-state brain networks.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
  2. The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Early Life Exposure to ΔCannabis and cannabinoid research · 2025
    Article
  17. Article
  18. Evidence on the effect of in-utero cannabis exposure in neonates.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  19. Cannabinoids: Medicine or PoisonBalkan medical journal · 2025
    Article
  20. Prenatal Downregulation of CBThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Anissa BaraDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY, USA.ORCID 0000-0002-5721-2675
Jacqueline-Marie N FerlandDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY, USA.
Gregory RompalaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY, USA.
Henrietta SzutoriszDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY, USA.
Yasmin L HurdDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, Mount Sinai, NY, USA. yasmin.hurd@mssm.edu.ORCID 0000-0003-0808-2832
Allen Institute for Brain Science · US

Funding

Transcription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Anne Schaefer · 2019 to 2026
$16.5M
Neurodevelopmental Effects of Cannabis and its Epigenetic RegulationR01DA030359 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HURD, YASMIN L. · 2011 to 2020
$5.5M
Heritable epigenetic mechanisms of paternal THC exposureF32DA050403 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROMPALA, GREGORY RONALD · 2020 to 2021
$80k
NIDA NIH HHS F32 DA050403NIDA NIH HHS P01 DA047233NIDA NIH HHS R01 DA030359
6 · The paper itself

Abstract

Recent years have been transformational in regard to the perception of the health risks and benefits of cannabis with increased acceptance of use. This has unintended neurodevelopmental implications given the increased use of cannabis and the potent levels of Δ

Indexed as

CannabisPrenatal Exposure Delayed EffectsAdolescentAdultAge FactorsAnimalsBrainChildChild, PreschoolDronabinolEndocannabinoidsEpigenesis, GeneticFemaleHumansInfantLactationDronabinolEndocannabinoidsLipaseNeurotransmitter AgentsReceptor, Cannabinoid, CB1

Identifiers

PMID34021274
PMCPMC8445589
OpenAlexW3160286893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.