Evidence map›Paper›PMID 34021235›Full record

ArticleNPJ digital medicine2021

Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19.

Sonu Subudhi, Ashish Verma, Ankit B Patel, C Corey Hardin, Melin J Khandekar, Hang Lee, Dustin McEvoy, Triantafyllos Stylianopoulos, Lance L Munn, Sayon Dutta and 1 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Integrating Heart Rate Variability Improves Machine Learning-based Prediction of Panic Disorder Symptom Severity.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
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  19. Prediction models for COVID-19 disease outcomes.Emerging microbes & infections · 2024
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sonu SubudhiDepartment of Medicine/Gastroenterology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-5937-1880
Ashish Verma *Department of Medicine/Renal Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9497-6327
Ankit B Patel *Department of Medicine/Renal Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6812-1464
C Corey HardinDepartment of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Melin J KhandekarDepartment of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9033-3241
Hang LeeBiostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Dustin McEvoyMass General Brigham Digital Health eCare, Somerville, MA, USA.ORCID http://orcid.org/0000-0002-5860-1541
Triantafyllos StylianopoulosCancer Biophysics Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus.
Lance L MunnEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0698-7232
Sayon DuttaMass General Brigham Digital Health eCare, Somerville, MA, USA. sdutta1@partners.org.ORCID http://orcid.org/0000-0002-0381-6860
Rakesh K JainEdwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. jain@steele.mgh.harvard.edu.ORCID http://orcid.org/0000-0001-7571-3548

Funding

Dissecting Pediatric Brain Tumor Microenvironment to Improve TreatmentR35CA197743 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K. · 2015 to 2020
$5.7M
Reprogramming PDAC tumor microenvironment to improve immunotherapyU01CA224348 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BOUCHER, YVES, JAIN, RAKESH K. · 2017 to 2021
$2.9M
Reengineering obesity-induced abnormal microenvironment to improve PDAC treatmentR01CA208205 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FUKUMURA, DAI, JAIN, RAKESH K. · 2017 to 2020
$2.2M
Vascularized tumor explants for drug testingR01CA247441 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L. · 2021 to 2025
$1.9M
Multiplexed device for rapid coagulopathy testingR21EB031982 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI HARDIN, CHARLES COREY, MUNN, LANCE L. · 2021 to 2021
$462k
NCI NIH HHS R01 CA208205NCI NIH HHS R01 CA247441NCI NIH HHS R35 CA197743NCI NIH HHS U01 CA224348NIBIB NIH HHS R21 EB031982
6 · The paper itself

Abstract

As predicting the trajectory of COVID-19 is challenging, machine learning models could assist physicians in identifying high-risk individuals. This study compares the performance of 18 machine learning algorithms for predicting ICU admission and mortality among COVID-19 patients. Using COVID-19 patient data from the Mass General Brigham (MGB) Healthcare database, we developed and internally validated models using patients presenting to the Emergency Department (ED) between March-April 2020 (n = 3597) and further validated them using temporally distinct individuals who presented to the ED between May-August 2020 (n = 1711). We show that ensemble-based models perform better than other model types at predicting both 5-day ICU admission and 28-day mortality from COVID-19. CRP, LDH, and O

Identifiers

PMID34021235
PMCPMC8140139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.