Evidence map›Paper›PMID 34021159›Full record

ArticleNPJ vaccines2021

Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques.

Michael K McCracken, Caitlin H Kuklis, Chandrika B Kannadka, David A Barvir, Mark A Sanborn, Adam T Waickman, Hayden C Siegfried, Kaitlin A Victor, Kristin L Hatch, Rafael De La Barrera and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Post-genomic platform for development of oligonucleotide vaccines against RNA viruses: diamond cuts diamond.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Article
  8. Anti-coronavirus vaccines will not accelerate the transition of humanity to a non-pandemic period, but the pandemic will take fewer victims.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Michael K McCrackenViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Caitlin H KuklisViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Chandrika B KannadkaViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
David A BarvirViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Mark A SanbornViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Adam T WaickmanViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Hayden C SiegfriedViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.ORCID http://orcid.org/0000-0002-0867-7943
Kaitlin A VictorViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Kristin L HatchViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Rafael De La BarreraPilot Bioproduction Facility, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Shannon D WallsViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Wiriya RutvisuttinuntViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Jeffrey R CurrierViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.ORCID http://orcid.org/0000-0002-5696-0268
Heather FribergViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Richard G JarmanViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA.
Gregory D GromowskiViral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MA, USA. gregory.d.gromowski.civ@mail.mil.ORCID http://orcid.org/0000-0003-4576-4277
Walter Reed Army Institute of Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibody-dependent enhancement (ADE) is suspected to influence dengue virus (DENV) infection, but the role ADE plays in vaccination strategies incorporating live attenuated virus components is less clear. Using a heterologous prime-boost strategy in rhesus macaques, we examine the effect of priming with DENV purified inactivated vaccines (PIVs) on a tetravalent live attenuated vaccine (LAV). Sera exhibited low-level neutralizing antibodies (NAb) post PIV priming, yet moderate to high in vitro ADE activity. Following LAV administration, the PIV primed groups exhibited DENV-2 LAV peak viremias up to 1,176-fold higher than the mock primed group, and peak viremia correlated with in vitro ADE. Furthermore, PIV primed groups had more balanced and higher DENV-1-4 NAb seroconversion and titers than the mock primed group following LAV administration. These results have implications for the development of effective DENV vaccine prime-boost strategies and for our understanding of the role played by ADE in modulating DENV replication.

Identifiers

PMID34021159
PMCPMC8140083
OpenAlexW3162584919

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.