ArticleNature communications2021
2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 43 citations in OpenAlex.
- Continuous UV irradiation played an inconclusive role in selecting the canonical genetic alphabet.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Strand Structure Controls Photoinduced Self-Repair of RNA Uracil Dimers.The journal of physical chemistry letters · 2026Article
- Accurate Prediction of Photoinduced Electron Transfer Timescales with Nonadiabatic Microcanonical Rate Theory.The journal of physical chemistry letters · 2026Article
- Article
- Diaminopurine in Nonenzymatic RNA Template Copying.Journal of the American Chemical Society · 2024Article
- Photoinduced charge separation and DNA self-repair depend on sequence directionality and stacking pattern.Chemical science · 2024Article
- Supramolecular Nature of Multicomponent Crystals Formed from 2,2'-Thiodiacetic Acid with 2,6-Diaminopurine or N9-(2-Hydroxyethyl)adenine.International journal of molecular sciences · 2023Article
- H(N3)dap (Hdap = 2,6-Diaminopurine) Recognition by CuMolecules (Basel, Switzerland) · 2023Article
- Photochemistry of 2-thiooxazole: a plausible prebiotic precursor to RNA nucleotides.Physical chemistry chemical physics : PCCP · 2022Article
- Transcriptional Perturbations of 2,6-Diaminopurine and 2-Aminopurine.ACS chemical biology · 2022Article
- Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides.The journal of physical chemistry letters · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
High-yielding and selective prebiotic syntheses of RNA and DNA nucleotides involve UV irradiation to promote the key reaction steps and eradicate biologically irrelevant isomers. While these syntheses were likely enabled by UV-rich prebiotic environment, UV-induced formation of photodamages in polymeric nucleic acids, such as cyclobutane pyrimidine dimers (CPDs), remains the key unresolved issue for the origins of RNA and DNA on Earth. Here, we demonstrate that substitution of adenine with 2,6-diaminopurine enables repair of CPDs with yields reaching 92%. This substantial self-repairing activity originates from excellent electron donating properties of 2,6-diaminopurine in nucleic acid strands. We also show that the deoxyribonucleosides of 2,6-diaminopurine and adenine can be formed under the same prebiotic conditions. Considering that 2,6-diaminopurine was previously shown to increase the rate of nonenzymatic RNA replication, this nucleobase could have played critical roles in the formation of functional and photostable RNA/DNA oligomers in UV-rich prebiotic environments.
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Registered trials
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