Evidence map›Paper›PMID 34021152›Full record

ArticleNature communications2021

Prevalence of SARS-CoV-2 antibodies in France: results from nationwide serological surveillance.

Stéphane Le Vu, Gabrielle Jones, François Anna, Thierry Rose, Jean-Baptiste Richard, Sibylle Bernard-Stoecklin, Sophie Goyard, Caroline Demeret, Olivier Helynck, Nicolas Escriou and 13 more

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Seroprevalence of SARS-CoV-2 Antibodies in Africa: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
  3. Trial
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  7. Use of cell phone data to correct Île-de-France population estimates and SARS-CoV-2 incidence, July to September, 2021: a proof-of-concept exercise.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Stéphane Le Vu *Infectious Diseases Division, Santé publique France, Saint-Maurice, France. stephane.levu@gmail.com.ORCID 0000-0002-1303-8281
Gabrielle Jones *Infectious Diseases Division, Santé publique France, Saint-Maurice, France.ORCID 0000-0001-9441-4172
François Anna *Unit of Molecular Virology and Vaccinology, Virology Department, Theravectys, Institut Pasteur, Paris, France.
Thierry Rose *Unit of Lymphocyte Cell Biology, Immunology Department, INSERM 1221, Institut Pasteur, Paris, France.
Jean-Baptiste RichardData Sciences Division, Santé publique France, Saint-Maurice, France.ORCID 0000-0002-4193-9159
Sibylle Bernard-StoecklinInfectious Diseases Division, Santé publique France, Saint-Maurice, France.
Sophie GoyardUnit of Lymphocyte Cell Biology, Immunology Department, INSERM 1221, Institut Pasteur, Paris, France.
Caroline DemeretUnit of Molecular Genetics of RNA Viruses, UMR 3569 CNRS, University of Paris-Diderot, Institut Pasteur, Paris, France.ORCID 0000-0002-1103-6805
Olivier HelynckUnit of Chemistry and Biocatalysis, UMR 3523 CNRS, Institut Pasteur, Paris, France.
Nicolas EscriouInnovation Laboratory: Vaccines, Institut Pasteur, Paris, France.
Marion GransagneInnovation Laboratory: Vaccines, Institut Pasteur, Paris, France.
Stéphane PetresProduction and Purification of Recombinant Proteins Technological Platform, Institut Pasteur, Paris, France.
Corinne RobinCerba Healthcare Division, Cerba Xpert, St Ouen L'Aumone, France.
Virgile MonnetEurofins Biomnis Sample Library, Eurofins Biomnis, Lyon, France.
Louise Perrin de FacciICAReB Biobanking Platform, Center for Translational Science, Institut Pasteur, Paris, France.ORCID 0000-0003-2821-4759
Marie-Noelle UngeheuerICAReB Biobanking Platform, Center for Translational Science, Institut Pasteur, Paris, France.
Lucie LéonRegional Office-French Caribbean, Santé publique France, Gourbeyre, France.
Yvonnick GuilloisRegional Office-Brittany, Santé publique France, Rennes, France.
Laurent FilleulRegional Office-Nouvelle Aquitaine, Santé publique France, Bordeaux, France.
Pierre CharneauUnit of Molecular Virology and Vaccinology, Virology Department, Theravectys, Institut Pasteur, Paris, France.
Daniel Lévy-BruhlInfectious Diseases Division, Santé publique France, Saint-Maurice, France.
Sylvie van der WerfUnit of Molecular Genetics of RNA Viruses, UMR 3569 CNRS, University of Paris-Diderot, Institut Pasteur, Paris, France.ORCID 0000-0002-1148-4456
Harold NoelInfectious Diseases Division, Santé publique France, Saint-Maurice, France.ORCID 0000-0003-3011-9267

Funding

Medical Research Council MC_PC_19012Medical Research Council MR/R015600/1
6 · The paper itself

Abstract

Assessment of the cumulative incidence of SARS-CoV-2 infections is critical for monitoring the course and extent of the COVID-19 epidemic. Here, we report estimated seroprevalence in the French population and the proportion of infected individuals who developed neutralising antibodies at three points throughout the first epidemic wave. Testing 11,000 residual specimens for anti-SARS-CoV-2 IgG and neutralising antibodies, we find nationwide seroprevalence of 0.41% (95% CI: 0.05-0.88) mid-March, 4.14% (95% CI: 3.31-4.99) mid-April and 4.93% (95% CI: 4.02-5.89) mid-May 2020. Approximately 70% of seropositive individuals have detectable neutralising antibodies. Infection fatality rate is 0.84% (95% CI: 0.70-1.03) and increases exponentially with age. These results confirm that the nationwide lockdown substantially curbed transmission and that the vast majority of the French population remained susceptible to SARS-CoV-2 in May 2020. Our study shows the progression of the first epidemic wave and provides a framework to inform the ongoing public health response as viral transmission continues globally.

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, ViralChildChild, PreschoolCOVID-19EpidemicsFemaleFranceHumansInfantInfant, NewbornMaleMiddle AgedAntibodies, Viral

Identifiers

PMID34021152
PMCPMC8140151

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.