ArticleNature communications2021
Transcriptional signature in microglia associated with Aβ plaque phagocytosis.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 202 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 4 pooled it
30.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
202 citing papers in PubMed, 4 syntheses or guidelines pooled it, 393 citations in OpenAlex.
- Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Identification of methylation-regulated genes modulating microglial phagocytosis in hyperhomocysteinemia-exacerbated Alzheimer's disease.Alzheimer's research & therapy · 2023Pooled it
- Pooled it
- Pooled it
- Spatiotemporal heterogeneity and dynamic evolution of microglial glucose metabolic reprogramming in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.Nature neuroscience · 2026Article
- Human iPSC models revealResearch square · 2026Article
- Bone marrow myelopoiesis dysfunction in Alzheimer's disease limits monocyte homing to the brain and drives disease progression.Nature neuroscience · 2026Article
- uPAR exhibits age- and region-dependent expression in the brains of mice with Alzheimer's disease-like pathology.Brain research · 2026Article
- DeepPlaque: a scalable multimodal platform for Aβ pathology and cell analysis in Alzheimer's disease.EMBO molecular medicine · 2026Article
- Hypothalamic neurovascular and extracellular matrix remodeling: Cellular niche orchestration of immune-metabolic adaptation to nutritional stress.Reviews in endocrine & metabolic disorders · 2026Review
- Modelling ischaemic AKI in human kidney organoids reveals injury-associated epithelial states and macrophage-epithelial crosstalk.Genome medicine · 2026Article
- An ApoE-Associated Low-Inflammatory Microglial State Emerges After Inflammatory Challenge in Alzheimer's Disease Mice.Neuroscience bulletin · 2026Article
- APOE3 and APOE4 human astrocytes differentially modulate Alzheimer's disease pathology and microglial responses in chimeric mice.Cell reports · 2026Article
- Gamma-type immunoglobulin enhances phagocytosis of amyloid-beta fibrils by microglia.Neural regeneration research · 2026Article
- Article
- Passive amyloid-β immunotherapy in Alzheimer's disease: a multicellular clearance system beyond plaque removal.Molecular neurodegeneration · 2026Review
- Cluster replicability in single-cell and single-nucleus atlases of the mouse brain.Nature communications · 2026Article
- Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer's disease.Molecular psychiatry · 2026Article
- A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex.Science (New York, N.Y.) · 2026Article
142 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 6 institutions in 3 countries.
Alexandra Grubman *Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia. alexandra.grubman@monash.edu.ORCID 0000-0003-4408-4499
Xin Yi Choo *Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-1783-0102
Gabriel Chew *Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, 169857, Singapore, Singapore.
John F OuyangProgram in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, 169857, Singapore, Singapore.ORCID 0000-0002-1239-1577
Guizhi SunDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
Nathan P CroftDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-2128-5127
Fernando J RosselloDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
Rebecca SimmonsARC Center of Excellence in Plant Energy Biology, The University of Western Australia, Perth, WA, Australia.
Sam BuckberryARC Center of Excellence in Plant Energy Biology, The University of Western Australia, Perth, WA, Australia.ORCID 0000-0003-2388-6046
Dulce Vargas LandinARC Center of Excellence in Plant Energy Biology, The University of Western Australia, Perth, WA, Australia.ORCID 0000-0002-4773-9406
Jahnvi PfluegerARC Center of Excellence in Plant Energy Biology, The University of Western Australia, Perth, WA, Australia.
Teresa H VandekolkMonash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC, Australia.
Zehra AbayDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
Yichen ZhouDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
Xiaodong LiuDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-9315-3406
Joseph ChenDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
Michael LarcombeDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
John M HaynesMonash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC, Australia.
Catriona McLeanVictorian Brain Bank, Parkville, VIC, Australia.
Sarah WilliamsDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia.
Siew Yeen ChaiDepartment of Physiology, Monash University, Clayton, VIC, Australia.
Trevor WilsonMHTP Medical Genomics Facility, Clayton, VIC, Australia.
Ryan ListerARC Center of Excellence in Plant Energy Biology, The University of Western Australia, Perth, WA, Australia.ORCID 0000-0001-6637-7239
Colin W PoutonMonash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, VIC, Australia.ORCID 0000-0003-0224-3308
Anthony W PurcellDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-0532-8331
Owen J L RackhamProgram in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, 169857, Singapore, Singapore.ORCID 0000-0002-4390-0872
Enrico PetrettoProgram in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, 169857, Singapore, Singapore. enrico.petretto@duke-nus.edu.sg.ORCID 0000-0003-2163-5921
Jose M PoloDepartment of Anatomy and Developmental Biology, Monash University, Clayton, VIC, Australia. jose.polo@monash.edu.ORCID 0000-0002-2531-778X
Australian Regenerative Medicine Institute · AUThe University of Western Australia · AUMonash University · AUNational University of Singapore · SGDiscovery Institute · USThe University of Melbourne · AU
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4
Indexed as
AgedAged, 80 and overAlzheimer DiseaseAnimalsBrainDisease Models, AnimalFemaleGene ExpressionGene Regulatory NetworksHumansHypoxia-Inducible Factor 1, alpha SubunitMaleMiceMicrogliaMiddle AgedPhagocytosisHif1a protein, mouseHypoxia-Inducible Factor 1, alpha Subunit
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.