ArticleTranslational psychiatry2021
Characteristics of mental health implications and plasma metabolomics in patients recently recovered from COVID-19.
Article in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Brain microstructural alterations in COVID-19: a systematic review of diffusion weighted imaging studies.Brain imaging and behavior · 2026Pooled it
- Post-COVID-19 conditions: a systematic review on advanced magnetic resonance neuroimaging findings.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Is self-report brain fog after mild COVID-19 truly induced by COVID-19 infection? A longitudinal fNIRS study.Dialogues in clinical neuroscience · 2026Article
- Brain metabolite changes in neonates of mothers with SARS-CoV-2 infection during pregnancy: a case-control study.Pediatric radiology · 2026Article
- Longitudinal alterations in morphological brain networks and cognitive function in common-type COVID-19: a 3-month follow-up study.Frontiers in neurology · 2025Article
- COVID-19 and Comorbidities: What Has Been Unveiled by Metabolomics?Metabolites · 2024Review
- The impact of inflammatory and metabolic markers on depression, anxiety, and cognition after COVID-19: a narrative review.Trends in psychiatry and psychotherapy · 2024Review
- On the merits and potential of advanced neuroimaging techniques in COVID-19: A scoping review.NeuroImage. Clinical · 2024Article
- Article
- Altered intrinsic brain activity and functional connectivity in COVID-19 hospitalized patients at 6-month follow-up.BMC infectious diseases · 2023Article
- Changes in Brain Activation Patterns During Working Memory Tasks in People With Post-COVID Condition and Persistent Neuropsychiatric Symptoms.Neurology · 2023Article
- Psychoanalysis of COVID-19 Patient Narratives: A Descriptive Study.Medicina (Kaunas, Lithuania) · 2023Article
- Abnormal brain diffusivity in participants with persistent neuropsychiatric symptoms after COVID-19.NeuroImmune pharmacology and therapeutics · 2023Article
- Longitudinal changes in global structural brain connectivity and cognitive performance in former hospitalized COVID-19 survivors: an exploratory study.Experimental brain research · 2023Article
- NMR-Metabolomics in COVID-19 Research.Advances in experimental medicine and biology · 2023Article
- Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms.Brain : a journal of neurology · 2022Article
- Article
- Persistent white matter changes in recovered COVID-19 patients at the 1-year follow-up.Brain : a journal of neurology · 2022Article
- [COVID-19: neurological manifestations-update : What we know so far].Der Radiologe · 2021Review
- Identifying cerebral microstructural changes in patients with COVID-19 using MRI: A systematic review.Brain circulationReview
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
This study aimed to explore the associations between cerebral white matter (WM) alterations, mental health status, and metabolism in recovered COVID-19 patients. We included 28 recovered COVID-19 patients and 27 healthy controls between April 2020 and June 2020. Demographic data, the mental health scores, diffusion-tensor imaging (DTI) data, and plasma metabolomics were collected and compared between the two groups. Tract-based spatial statistics and graph theory approaches were used for DTI data analysis. Untargeted metabolomics analysis of the plasma was performed. Correlation analyses were performed between these characteristics. Recovered COVID-19 patients showed decreased fractional anisotropy, increased mean diffusivity and radial diffusivity values in widespread brain regions, and significantly lower global efficiency, longer shortest path length, and less nodal local efficiency in superior occipital gyrus (all, P < 0.05, Bonferroni corrected). Our results also demonstrated significantly different plasma metabolic profiling in recovered COVID-19 patients even at 3 months after their hospital discharge, which was mainly related to purine pathways, amino acids, lipids, and amine metabolism. Certain regions with cerebral WM alterations in the recovered patients showed significant correlations with different metabolites and the mental health scores. We observed multiple alterations in both WM integrity and plasma metabolomics that may explain the deteriorated mental health of recovered COVID-19 patients. These findings may provide potential biomarkers for the mental health evaluation for the recovered COVID-19 patients and potential targets for novel therapeutics.
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