Evidence map›Paper›PMID 34021061›Full record

ArticleTobacco control2023

Characterisation of vaping liquids used in vaping devices across four countries: results from an analysis of selected vaping liquids reported by users in the 2016 ITC Four Country Smoking and Vaping Survey.

Brian Vincent Fix, Richard J OConnor, Maciej Lukasz Goniewicz, Noel L Leigh, Michael Cummings, Sara C Hitchman, Geoffrey T Fong, Georges El Nahas, David Hammond, Ann McNeill and 3 more

Abstract read
In one paragraph

Article in Tobacco control, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Biomarkers of Toxicant Exposure among Youth in Canada, England, and the United States Who Vape and/or Smoke Tobacco or Do Neither.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brian Vincent FixDept. of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA brian.fix@roswellpark.org.ORCID 0000-0001-9135-4290
Richard J OConnorDept. of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Maciej Lukasz GoniewiczDept. of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.ORCID 0000-0001-6748-3068
Noel L LeighDept. of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Michael CummingsPsychiatry & Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0002-7103-7017
Sara C HitchmanDepartment of Addictions, King's College London, London, UK.ORCID 0000-0001-6155-6916
Geoffrey T FongPsychology, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0001-9098-6472
Georges El NahasHollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA.
David HammondSchool of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.
Ann McNeillUK Centre for Tobacco Control Studies, National Addiction Centre, Institute of Psychiatry, King's College London, London, UK.ORCID 0000-0002-6223-4000
Ron BorlandSchool of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia.
Bill KingVichealth Centre for Tobacco Control, cancer council victoria, Carlton, Victoria, Australia.ORCID 0000-0001-5789-1236
Mary N PalumboDept. of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Christine B. Ambrosone · 1985 to 2026
$116.6M
Vaporized Nicotine Product Initiation Among Youth in the US, Canada, and England: Methods to Predict Uptake and Policy EfficacyP01CA200512 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEVY, DAVID THEODORE · 2016 to 2025
$25.3M
WNY Center for Research on Flavored Tobacco Products (CRoFT)U54CA228110 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI LI, DONGMEI · 2018 to 2022
$19.8M
CIHR FDN‐148477NCI NIH HHS P01 CA200512NCI NIH HHS P30 CA016056NCI NIH HHS U54 CA228110
6 · The paper itself

Abstract

objectivesThis study presents an analysis of vaping products (VPs) purchased in the USA, Canada, England and Australia and assesses whether differences in regulations were associated with differences in the chemical composition of the VPs.

methodsApril-September 2017, a total of 234 VP refill liquids and prefilled cartridges were purchased in convenience samples of retail locations in each country. Products were chosen from brands and styles most commonly reported by current VP users in the 2016 ITC Four Country Smoking and Vaping Survey. All products were tested for nicotine, tobacco-specific nitrosamines (TSNAs), minor tobacco alkaloids, organic acids and flavouring chemicals.

resultsConsistent with the laws in Canada and Australia at the time of product purchase, nicotine was not detected in any of the VPs (n=10 in Canada; n=15 in Australia). US liquids (n=54) had a mean nicotine concentration of 16.2 mg/mL, (range=0.0-58.6) and English liquids (n=166) had a mean concentration of 11.9 mg/mL ((range=0.0-31.2) F(3244)=12.32, p<0.001). About 5% of English samples exceeded the UK's 20 mg/mL nicotine limit. Substantial country differences were observed in levels ofTSNAs, with the USA being higher than elsewhere. Of all products tested, 18.8% contained at least one organic acid. Liquids purchased in England contained far more identifiable flavouring chemicals than those in the other countries.

conclusionsVP composition, particularly with respect to nicotine and flavouring, varies by country, likely reflecting both marketplace preferences and country-specific regulations. There are differences between nicotine levels claimed on the package and actual levels, particularly in England.

Indexed as

Electronic Nicotine Delivery SystemsVapingFlavoring AgentsHumansNicotineSmokingSurveys and QuestionnairesTobacco SmokingFlavoring AgentsNicotineelectronic nicotine delivery devicesnicotinepublic policy

Identifiers

PMID34021061
PMCPMC9326900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.