Evidence map›Paper›PMID 34021044›Full record

ArticleDiabetes2021

Metabolomics Profiling of Patients With A-β+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis.

Farook Jahoor, Jean W Hsu, Paras B Mehta, Kelly R Keene, Ruchi Gaba, Surya Narayan Mulukutla, Eunice Caducoy, W Frank Peacock, Sanjeet G Patel, Rasmus Bennet and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  9. High Prevalence ofPediatric diabetes · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Farook JahoorChildren's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX.
Jean W HsuChildren's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX.
Paras B MehtaDivision of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.ORCID 0000-0001-5434-5424
Kelly R KeeneDepartment of Emergency Medicine, Baylor College of Medicine, Houston, TX.
Ruchi GabaDivision of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.
Surya Narayan MulukutlaDiabetes and Endocrinology Institute, DHR Health, Edinburg, TX.ORCID 0000-0002-0447-0638
Eunice CaducoyChildren's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX.
W Frank PeacockDepartment of Emergency Medicine, Baylor College of Medicine, Houston, TX.
Sanjeet G PatelDivision of Cardiothoracic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Rasmus BennetUnit for Diabetes and Celiac Disease, Lund University, Malmo, Sweden.
Ake LernmarkUnit for Diabetes and Celiac Disease, Lund University, Malmo, Sweden.ORCID 0000-0003-1735-0499
Ashok BalasubramanyamDivision of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX ashokb@bcm.tmc.edu.ORCID 0000-0003-2093-5201
Baylor College of Medicine · USAgricultural Research Service · USLund University · SEDoctors Hospital at Renaissance · USUniversity of Southern California · US

Funding

Arginine and Nitric Oxide Synthesis in the Pathogenesis of Ketosis-Prone DiabetesR01DK101411 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI BALASUBRAMANYAM, ASHOK, JAHOOR, FAROOK · 2014 to 2018
$2.1M
NIDDK NIH HHS R01 DK101411
6 · The paper itself

Abstract

When stable and near-normoglycemic, patients with "A-β+" ketosis-prone diabetes (KPD) manifest accelerated leucine catabolism and blunted ketone oxidation, which may underlie their proclivity to develop diabetic ketoacidosis (DKA). To understand metabolic derangements in A-β+ KPD patients during DKA, we compared serum metabolomics profiles of adults during acute hyperglycemic crises, without (

Indexed as

AdultAmino Acids, Branched-ChainAutoantibodiesCarnitineDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic KetoacidosisFemaleHumansMaleMetabolomeMetabolomicsMiddle AgedacylcarnitineAmino Acids, Branched-ChainAutoantibodiesCarnitine

Identifiers

PMID34021044
PMCPMC8385613
OpenAlexW3163947768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.