Evidence map›Paper›PMID 34021031›Full record

Trial reportClinical journal of the American Society of Nephrology : CJASN2021

Nephrologist Follow-Up versus Usual Care after an Acute Kidney Injury Hospitalization (FUSION): A Randomized Controlled Trial.

Samuel A Silver, Neill K Adhikari, Chaim M Bell, Christopher T Chan, Ziv Harel, Abhijat Kitchlu, Alejandro Meraz-Muñoz, Patrick A Norman, Adic Perez, Alireza Zahirieh and 1 more

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical journal of the American Society of Nephrology : CJASN, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02483039 (Nephrologist Follow-up Versus Usual Care After an Acute Kidney Injury Hospitalization), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02483039 naunknown statusnot on this map

Nephrologist Follow-up Versus Usual Care After an Acute Kidney Injury Hospitalization (FUSION): Vanguard Phase of a Randomized Controlled Trial

TypeinterventionalSponsorUnity Health TorontoRan2015 to 2022Enrolled200ConditionsAcute Kidney Injury, Chronic Kidney DiseaseArmsAKI Follow-up Clinic
3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Preventable Hospitalizations and Kidney Care.Clinical journal of the American Society of Nephrology : CJASN · 2026
    Review
  14. Article
  15. Review
  16. SGLT2 Inhibitors and Long-Term Outcomes After AKI.Kidney international reports · 2026
    Article
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Samuel A SilverDivision of Nephrology, Kingston Health Sciences Centre, Queen's University, Kingston, Ontario, Canada.ORCID 0000-0002-1843-6131
Neill K AdhikariDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Chaim M BellInstitute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Christopher T ChanDivision of Nephrology, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
Ziv HarelDivision of Nephrology and Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8618-4538
Abhijat KitchluDivision of Nephrology, University Health Network-Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-4340-5046
Alejandro Meraz-MuñozDivision of Nephrology and Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-8174-1235
Patrick A NormanKingston General Health Research Institute, Kingston, Ontario, Canada.
Adic PerezDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Alireza ZahiriehDivision of Nephrology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.
Ron WaldDivision of Nephrology and Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
St. Michael's Hospital · CASunnybrook Health Science Centre · CAQueen's University · CAUniversity Health Network · CAMount Sinai Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesSurvivors of AKI are at higher risk of CKD and death, but few patients see a nephrologist after hospital discharge. Our objectives during this 2-year vanguard phase trial were to determine the feasibility of randomizing survivors of AKI to early follow-up with a nephrologist or usual care, and to collect data on care processes and outcomes. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a randomized controlled trial in patients hospitalized with Kidney Disease Improving Global Outcomes (KDIGO) stage 2-3 AKI at four hospitals in Toronto, Canada. We randomized patients to early nephrologist follow-up (standardized basket of care that emphasized BP control, cardiovascular risk reduction, and medication safety) or usual care from July 2015 to June 2017. Feasibility outcomes included the proportion of eligible patients enrolled, seen by a nephrologist, and followed to 1 year. The primary clinical outcome was a major adverse kidney event at 1 year, defined as death, maintenance dialysis, or incident/progressive CKD.

resultsWe screened 3687 participants from July 2015 to June 2017, of whom 269 were eligible. We randomized 71 (26%) patients (34 to nephrology follow-up and 37 to usual care). The primary reason stated for declining enrollment included hospitalization-related fatigue (

conclusionsMajor adverse kidney events are common in AKI survivors, but we found the in-person model of follow-up posed a variety of barriers that was not acceptable to many patients. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Nephrologist Follow-up versus Usual Care after an Acute Kidney Injury Hospitalization (FUSION), NCT02483039 CJASN 16: 1005-1014, 2021. doi: https://doi.org/10.2215/CJN.17331120.

Indexed as

AftercareNephrologistsPatient Acceptance of Health CareAcute Kidney InjuryAgedDisease ProgressionFeasibility StudiesFemaleHospitalizationHumansMaleMiddle AgedNephrologyPilot ProjectsRenal DialysisRenal Insufficiency, Chronicacute kidney injuryacute renal failurechronic kidney diseasehospitalizationnephrologistsprogression of chronic renal failurerandomized controlled trials

Identifiers

PMID34021031
PMCPMC8425610
OpenAlexW3161398507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.