Evidence map›Paper›PMID 34020961›Full record

ArticleScience advances2021

A flexible multiplexed immunosensor for point-of-care in situ wound monitoring.

Yuji Gao, Dat T Nguyen, Trifanny Yeo, Su Bin Lim, Wei Xian Tan, Leigh Edward Madden, Lin Jin, Ji Yong Kenan Long, Fazila Abu Bakar Aloweni, Yi Jia Angela Liew and 10 more

Abstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed.

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  9. Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  19. [Researches and clinical translation of smart dressings].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025
    Review
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Yuji GaoInstitute for Health Innovation & Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore. yujigao2021@gmail.com ctlim@nus.edu.sg.ORCID 0000-0001-7222-647X
Dat T NguyenIntegrative Sciences and Engineering Programme, NUS Graduate School, National University of Singapore, Singapore 119077, Singapore.ORCID 0000-0003-2750-3145
Trifanny YeoDepartment of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.
Su Bin LimDepartment of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0003-1752-7039
Wei Xian TanNursing, Singapore General Hospital, Singapore 168753, Singapore.
Leigh Edward MaddenLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0000-0003-1111-9288
Lin JinDepartment of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore.ORCID 0000-0002-2059-2571
Ji Yong Kenan LongDepartment of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.
Fazila Abu Bakar AloweniNursing, Singapore General Hospital, Singapore 168753, Singapore.ORCID 0000-0001-8435-5068
Yi Jia Angela LiewNursing, Singapore General Hospital, Singapore 168753, Singapore.
Mandy Li Ling TanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
Shin Yuh AngNursing, Singapore General Hospital, Singapore 168753, Singapore.
Sivagame D/O ManiyaNursing, Singapore General Hospital, Singapore 168753, Singapore.
Ibrahim AbdelwahabDepartment of Chemistry, National University of Singapore, Singapore 117543, Singapore.ORCID 0000-0002-0107-5827
Kian Ping LohDepartment of Chemistry, National University of Singapore, Singapore 117543, Singapore.ORCID 0000-0002-1491-743X
Chia-Hung ChenDepartment of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China.ORCID 0000-0001-5097-3968
David Laurence BeckerLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.ORCID 0000-0002-9300-0899
David LeavesleySkin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore.ORCID 0000-0002-1033-5459
John S HoInstitute for Health Innovation & Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore.ORCID 0000-0002-9458-9033
Chwee Teck LimInstitute for Health Innovation & Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore. yujigao2021@gmail.com ctlim@nus.edu.sg.ORCID 0000-0003-4019-9782

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the wound microenvironment, inflammation, and infection state at the point of care. This platform integrates a sensor array for measuring inflammatory mediators [tumor necrosis factor-α, interleukin-6 (IL-6), IL-8, and transforming growth factor-β1], microbial burden (

Indexed as

Biosensing TechniquesPoint-of-Care SystemsAnimalsHumansImmunoassayMiceTumor Necrosis Factor-alphaWound HealingTumor Necrosis Factor-alpha

Identifiers

PMID34020961
PMCPMC8139589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.