Evidence map›Paper›PMID 34020954›Full record

ArticleScience advances2021

Adult neural stem cells have latent inflammatory potential that is kept suppressed by

Mohammad Shariq, Vinaya Sahasrabuddhe, Sreevatsan Krishna, Swathi Radha, Nruthyathi, Ravishankara Bellampalli, Anukriti Dwivedi, Rajit Cheramangalam, Boris Reizis, Jean Hébert and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
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  7. Article
  8. MeCP2 gene therapy ameliorates disease phenotype in mouse model for Pitt Hopkins syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Regulation of microglia function by neural stem cells.Frontiers in cellular neuroscience · 2023
    Review
  14. Msx1Nature communications · 2022
    Article
  15. Circuit formation in the adult brain.The European journal of neuroscience · 2022
    Review
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Mohammad ShariqNational Centre for Biological Science, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore, India.ORCID 0000-0003-4766-6793
Vinaya SahasrabuddheNational Centre for Biological Science, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore, India.
Sreevatsan KrishnaNational Centre for Biological Science, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore, India.
Swathi RadhaNational Centre for Biological Science, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore, India.
NruthyathiNational Centre for Biological Science, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore, India.ORCID 0000-0002-1684-5468
Ravishankara BellampalliNational Centre for Biological Science, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore, India.
Anukriti DwivediNational Centre for Biological Science, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore, India.
Rajit CheramangalamNational Centre for Biological Science, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore, India.
Boris ReizisDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.ORCID 0000-0003-1140-7853
Jean HébertDepartments of Neuroscience and Genetics, Albert Einstein College of Medicine, New York, NY, USA.
Hiyaa S GhoshNational Centre for Biological Science, Tata Institute of Fundamental Research (NCBS-TIFR), Bangalore, India. hiyaa@ncbs.res.in.ORCID 0000-0001-6224-1043
National Centre for Biological Sciences · INAlbert Einstein College of Medicine · USNew York University · US

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Molecular Control of Plasmacytoid Dendritic Cell Development and FunctionR37AI072571 · NIAID · UNIVERSITY OF CHICAGO · PI Boris Reizis · 2018 to 2026
$5.3M
NIAID NIH HHS R37 AI072571NICHD NIH HHS P50 HD105352
6 · The paper itself

Abstract

Inflammation is known to adversely affect adult neurogenesis, wherein the source of inflammation is largely thought to be extraneous to the neurogenic niche. Here, we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 (

Indexed as

Dentate GyrusNeural Stem CellsTranscription Factor 4AnimalsInflammationMiceMice, Inbred C57BLMice, TransgenicNeurogenesisTcf4 protein, mouseTranscription Factor 4

Identifiers

PMID34020954
PMCPMC8139598
OpenAlexW3160277663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.