Evidence map›Paper›PMID 34020876›Full record

ReviewSeminars in cell & developmental biology2022

Synaptic modifications in learning and memory - A dendritic spine story.

Shaorong Ma, Yi Zuo

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Altered Structural Plasticity Mediated by mGlu and NMDA Receptors and Impaired Cognition in a Genetic ASD Model (Shank3The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
  3. Brain-Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety-Like Behaviors in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Developmental changes in brain-wide fear memory networks.Neurobiology of learning and memory · 2025
    Article
  8. Article
  9. Review
  10. Computational analysis of learning in young and ageing brains.Frontiers in computational neuroscience · 2025
    Article
  11. Article
  12. Selective Modulation of Fear Memory in Non-Rapid Eye Movement Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Analysis of Neuronal Morphology by Two-Photon Microscopy.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  20. Synaptopodin: a key regulator of Hebbian plasticity.Frontiers in cellular neuroscience · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shaorong MaDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
Yi ZuoDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA. Electronic address: yizuo@ucsc.edu.

Funding

Impact of sleep-wake circuits on cortical synapse plasticity during motor learningR01NS104950 · NINDS · STANFORD UNIVERSITY · PI MOURRAIN, PHILIPPE · 2018 to 2022
$2.6M
Contribution of astrocytes to the Fragile X SyndromeR01MH109475 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2016 to 2020
$2.0M
Explore the gut-immune-brain axis mechanisms underlying perinatal penicillin exposure-induced sensory processing defectsR21HD101266 · NICHD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2020 to 2021
$424k
NICHD NIH HHS R21 HD101266NIMH NIH HHS R01 MH109475NINDS NIH HHS R01 NS104950
6 · The paper itself

Abstract

Synapses are specialized sites where neurons connect and communicate with each other. Activity-dependent modification of synaptic structure and function provides a mechanism for learning and memory. The advent of high-resolution time-lapse imaging in conjunction with fluorescent biosensors and actuators enables researchers to monitor and manipulate the structure and function of synapses both in vitro and in vivo. This review focuses on recent imaging studies on the synaptic modification underlying learning and memory.

Indexed as

Dendritic SpinesSynapsesLearningNeuronsDendritic spineLearningLTDLTPMemorySynapse

Identifiers

PMID34020876
PMCPMC9547722

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.