Evidence map›Paper›PMID 34020813›Full record

ArticleVaccine2021

Influenza and pneumococcal vaccinations are not associated to COVID-19 outcomes among patients admitted to a university hospital.

Roberta Pastorino, Leonardo Villani, Daniele Ignazio La Milia, Roberto Ieraci, Francesco Chini, Enrico Volpe, Alessandra Barca, Danilo Fusco, Patrizia Laurenti, Walter Ricciardi and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Roberta PastorinoDepartment of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
Leonardo VillaniSection of Hygiene, University Department of Life Sciences and Public Health - Università Cattolica del Sacro Cuore, Rome, Italy. Electronic address: leonardo.villani01@icatt.it.
Daniele Ignazio La MiliaSection of Hygiene, University Department of Life Sciences and Public Health - Università Cattolica del Sacro Cuore, Rome, Italy.
Roberto IeraciLocal Health Units Vaccination Group - ASL Roma 1, Rome, Italy.
Francesco ChiniRegional Directorate for Health and Social Policy, Lazio Region, Rome, Italy.
Enrico VolpeRegional Directorate for Health and Social Policy, Lazio Region, Rome, Italy.
Alessandra BarcaRegional Directorate for Health and Social Policy, Lazio Region, Rome, Italy.
Danilo FuscoRegional Directorate for Health and Social Policy, Lazio Region, Rome, Italy.
Patrizia LaurentiDepartment of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Section of Hygiene, University Department of Life Sciences and Public Health - Università Cattolica del Sacro Cuore, Rome, Italy.
Walter RicciardiSection of Hygiene, University Department of Life Sciences and Public Health - Università Cattolica del Sacro Cuore, Rome, Italy.
Stefania BocciaDepartment of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Section of Hygiene, University Department of Life Sciences and Public Health - Università Cattolica del Sacro Cuore, Rome, Italy.
Università Cattolica del Sacro Cuore · ITRegione LazioAgostino Gemelli University Polyclinic · ITASL Roma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to reduce the burden on healthcare systems and to support differential diagnosis with COVID-19, influenza and pneumococcal vaccinations were strongly recommended during the COVID-19 pandemic, especially in vulnerable groups. However, no univocal and conclusive evidence on the relationship between influenza and pneumococcal vaccinations and COVID-19 outcomes exists. We evaluated the association between such vaccinations, COVID-19 hospitalization, intensive care unit admissions and deaths in a cohort (N = 741) of COVID-19 patients who had access to the emergency room of a large Italian University hospital between March 1, 2020 and June 1, 2020. Results show that influenza and pneumococcal vaccinations did not affect hospitalization, intensive care unit admission and deaths in COVID-19 patients in the overall sample and in those ≥65 years. The same pattern of results was confirmed considering timing of influenza vaccine administration, vaccination type, and number of uptakes in the last five vaccination campaigns. In conclusion, our study does not support an impact of influenza and pneumococcal vaccinations on COVID-19 outcomes.

Indexed as

COVID-19Influenza, HumanInfluenza VaccinesHospitalizationHumansItalyPandemicsPneumococcal VaccinesSARS-CoV-2VaccinationInfluenza VaccinesPneumococcal VaccinesCOVID-19Flu vaccinationHealth outcomesPneumococcal vaccination

Identifiers

PMID34020813
PMCPMC8106908
OpenAlexW3162931041

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.